Abstract-This paper reports on the development of an interactive, intraoperative dose planning system for seed implant brachytherapy in cancer treatment. This system involves in vivo dosimetry and the ability to determine implanted seed positions. The first stage of this project is the development of a urethral alarm probe to measure the dose along the urethra during a prostate brachytherapy treatment procedure. Ultimately, the system will be used to advise the physicians upon reaching a preset dose rate or dose after total seed decay in the urethra during the seed placement. The second stage is the development of a method and instrumentation for in vivo measurements of the location of implanted seeds in the same frame as for dose planning and the use of these in intraoperative treatment planning. We have developed a silicon mini-detector, miniature front-end, and shaping amplifier with discriminator, connected to the mini-silicon detector at the end of a cable placed in a urological catheter, to satisfy the spectroscopic requirements of the urethral probe. This technique will avoid complications related to overdosing the urethra and the rectum.
This study presents a high spatial resolution dosimetry system for quality assurance of I-125 eye plaques. The system is based on a silicon pixelated detector and is capable of deriving 3D dose. A simple design was implemented, incorporating a movable eye plaque in a small water phantom above the silicon Medipix detector. It is suitable for obtaining 2D planar dose images at different depths in water, for subsequent reconstruction. The effect of backscattering of a medium placed on the back of the Medipix has been studied in terms of dose distribution. Additionally, event counting mode on the detector was compared to the more complex time-over-threshold mode and the TG-43 protocol for determining its suitability in dosimetry.
HDR BrachyView is a novel in-body dosimetric imaging system for real-time monitoring and verification of the source position in high dose rate (HDR) prostate brachytherapy treatment. It is based on a high-resolution pixelated detector array with a semi-cylindrical multi-pinhole tungsten collimator and is designed to fit inside a compact rectal probe, and is able to resolve the 3D position of the source with a maximum error of 1.5 mm. This paper presents an evaluation of the additional dose that will be delivered to the patient as a result of backscatter radiation from the collimator. Monte Carlo simulations of planar and cylindrical collimators embedded in a tissue-equivalent phantom were performed using Geant4, with an 192 Ir source placed at two different sourcecollimator distances. The planar configuration was replicated experimentally to validate the simulations, with a MOSkin dosimetry probe used to measure dose at three distances from the collimator. For the cylindrical collimator simulation, backscatter dose enhancement was calculated as a function of axial and azimuthal displacement, and dose distribution maps were generated at three distances from the collimator surface. Although significant backscatter dose enhancement was observed for both geometries immediately adjacent to the collimator, simulations and experiments indicate that backscatter dose is negligible at distances beyond 1 mm from the collimator. Since HDR BrachyView is enclosed within a 1 mm thick tissue-equivalent plastic shell, all
Institute of Physics and Engineering in Medicine
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