Seven new pyrrolizidine alkaloids have been isolated. More details of the stereochemistry and conformations of pyrrolizidine alkaloids are emerging from the large number of structures that have been elucidated by X-ray crystallography. Macrocyclic pyrrolizidine alkaloid analogues that contain tenmembered rings have been prepared for the first time. The synthesis of the necine base (+)-crotanecine has been achieved.
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