Several recent meta-analyses appear to show a weak but significant effect of both forms of the gly/ser DRD3 polymorphism in conferring risk for schizophrenia. Since most studies have employed the artifact-prone case-control design, we thought it worthwhile to examine the role of this polymorphism using a robust family-based strategy in an ethnic group not previously systematically studied in psychiatric genetics, Palestinian Arabs. We failed to obtain any evidence in 129 Palestinian triads, using the haplotype relative risk (allele frequency: Pearson chi-square = 0.009, P > 0.1, df = 1, n = 258 alleles) or transmission disequilibrium test design (chi-square = 0.38, P > 0.1, n = 86 families) for association/linkage (or increased homozygosity) of the DRD3 Bal I polymorphism to schizophrenia in our sample. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:778-780, 2000.

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70s S46. Data bases for psychiatric research panic disorder, insomnia). The treatment has consisted of cognitivebehavioral self-help programs supported by e-mail interaction. Effect sizes in these studies are. equivalent to previous self-help studies on problems like panic disorder, and indicate that Internet-based treatment can serve as a cost-effective complement to psychological and psychiatric treatment. Important issues when implementing Internet-based treatment in clinical practice involve diagnoses, suitability, and compliance. Whereas self-report inventories can easily be adapted for Internet use, with similar psychometric properties as paper-and-pencil tests, it is more difficult to obtain reliable information on diagnoses. Future studies should address differences between ordinary and Internet-based treatments, and also the use of Internet-based treatment as an adjunct to pharmacological treatment.