No association between the dopamine D3 receptor Bal I polymorphism and schizophrenia in a family‐based study of a Palestinian Arab population

Kremer, I; Rietschel, Marcella; Dobrusin, M.; Mujaheed, Muhammed; Murad, I.; Blanaru, Monica; Bannoura, I.; Müller, D.J.; Schulze, Thomas G.; Reshef, Alon; Gathas, S.; Schwab, Stefan; Wildenauer, D.B.; Bachner‐Melman, Rachel; Belmaker, R.H.; Maier, Wolfgang; Ebstein, Richard P.

doi:10.1002/1096-8628(20001204)96:6<778::aid-ajmg16>3.3.co;2-u

Cited by 7 publications

(8 citation statements)

References 15 publications

(18 reference statements)

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“…Our results, obtained with two powerful strategies of association (HRR and TDT), indicate that the Ser9Gly polymorphism in the first exon of the DRD3 gene is unlikely to be involved in schizophrenia in our sample. Our findings are in accordance with case-control association studies (Jonsson et al, 1993;Nimgaonkar et al, 1993;Yang et al, 1993;Di Bella et al, 1994;Chen et al, 1997), and with family-based association studies (Macciardi et al, 1994;Rothschild et al, 1996;Prasad et al, 1999;Kremer et al, 2000). Although negative, our results can only exclude a very large effect of the investigated polymorphism on schizophrenia in this population.…”

Section: Discussionsupporting

confidence: 91%

“…Several case-control studies have investigated the possible involvement of the DRD2 and DRD3 genes in schizophrenia, but the results are inconclusive (Dubertret et al, 1998;Spurlock et al, 1998;Williams et al, 1998;Kremer et al, 2000;Hori et al, 2001;Himei et al, 2002;Morimoto et al, 2002). However, meta-analyses have recently supported the involvement of the DRD2 and DRD3 genes in the pathogenesis of schizophrenia (Jonsson et al, 2003a,b).…”

Section: Introductionmentioning

confidence: 99%

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Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population

Ambrosio

Kennedy

Macciardi

et al. 2004

Psychiatry Research

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Schizophrenia is a highly heritable condition, as demonstrated in family, twin and adoption studies. Candidate genes from the dopaminergic system have long been hypothesized to be involved in the etiology of this disorder. In the present study, we investigated the genetic association between polymorphisms in the D2 and D3 dopamine receptor (DRD2, DRD3) genes and schizophrenia. We examined 90 trios from Portugal, and negative results were obtained from association studies with both Haplotype Relative Risk (HRR) and Transmission Disequilibrium Test (TDT), as well as TRANSMIT. Therefore, we conclude that neither the DRD2 nor the DRD3 gene polymorphisms investigated are associated with schizophrenia in our sample.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population

Ambrosio

Kennedy

Macciardi

et al. 2004

Psychiatry Research

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“…The Ser9Gly (S/G) polymorphism of this receptor has been found to be associated with general susceptibility to schizophrenia [Spurlock et al, 1998; Williams et al, 1998], schizoaffective disorder [Meszaros et al, 2000], tardive dyskinesia [Steen et al, 1997; Lerer et al, 2002], akathisia [Eichhammer et al, 2000], spontaneous dyskinesia in never‐medicated schizophrenia patients [Lovlie et al, 2001], substance abuse in schizophrenia [Krebs et al, 1998], eye‐movement abnormalities [Rybakowski et al, 2001], and therapeutic response to clozapine [Shaikh et al, 1996; Scharfetter et al, 1999]. Negative studies have also been published, querying the relevance of the S/G polymorphism in schizophrenia [Malhotra et al, 1998; Kremer et al, 2000; Virgos et al, 2001].…”

Section: Introductionmentioning

confidence: 99%

Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia

Szekeres

Kéri

Juhász

et al. 2003

American J of Med Genetics Pt B

120

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Molecular components of the dopaminergic system may play an important role in the pathophysiology of schizophrenia. In this study, we investigated the relationship of the Ser9Gly (S/G) polymorphism of the dopamine D3 receptor (DRD3) and the variable number of tandem repeats (VNTR) polymorphism of the dopamine transporter (DAT) with therapeutic response to atypical antipsychotics (clozapine, olanzapine, quetiapine, risperidone) and cognitive functions. No associations were found between the DRD3 and DAT polymorphisms and schizophrenia. The S/S genotype and the S allele were more frequent in the non-responder patients (n = 28) than in the group of responders (n = 47) (cut-off: >20-point improvement in Global Assessment of Functioning (GAF) scale). The patients with S/S genotype completed fewer categories and had more perseverative errors in the Wisconsin Card Sorting Test (WCST) compared with the S/G patients. The S/S and S/G patients did not differ in positive and negative symptoms, GAF scores, WCST failure to maintain set, and verbal learning. No differences in symptoms or WCST measures were observed in the patients with different DAT genotypes. These results suggest that the S/S genotype of the DRD3 is associated with worse therapeutic response and more severe executive dysfunctions in patients with schizophrenia.

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“…A total of 13 articles were included in the present meta-analysis. 26,[38][39][40][41][42][43][44][45][46][47][48][49] Among them, 11 studies were for TDT and 5 studies were for HHRR. Table 1 showed the ORs and 95% CIs for the 11 TDT studies.…”

Section: Resultsmentioning

confidence: 99%

No relationship between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and schizophrenia: a meta-analysis of family-based association studies

Li¹,

Zheng²,

Wei³

et al. 2019

Preprint

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Background Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human dopamine receptor D3 gene (DRD3). It is still controversial that whether Ser9Gly is involved in the occurrence of schizophrenia. Thus, a meta-analysis of family-based studies was performed to explore the role of Ser9Gly in the etiology of schizophrenia. Methods The published family-based association studies were searched from the relevant literature databases according to the established inclusion criteria. We generated odds ratios and 95% confidence intervals in order to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia. Results We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HHRR) studies. There were no statistical significance for the heterogeneity in TDT and HHRR studies. Therefore, the fix effect model was used to measure the pooled effect size. The results showed that neither of the associations between Ser9Gly and the risk of schizophrenia were observed in TDT and HHRR studies, except for the significantly preferential transmission of DRD3 Ser9 allele in East Asian in TDT studies. Conclusions Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. However, more effects need to further confirm the function of DRD3 Ser9Gly SNP in the occurrence of schizophrenia.

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No association between the dopamine D3 receptor Bal I polymorphism and schizophrenia in a family‐based study of a Palestinian Arab population

Cited by 7 publications

References 15 publications

Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population

Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population

Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia

No relationship between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and schizophrenia: a meta-analysis of family-based association studies

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