This is the report of a series of eight patients with pulmonary hypertension (primary and secondary) who delivered at the

Model and observational evidence has shown that ocean current speeds in the Beaufort Gyre have increased and recently stabilized. Because these currents rival ice drift speeds, we examine the potential for the Beaufort Gyre's shift from a system in which the wind drives the ice and the ice drives a passive ocean to one in which the ocean often, in the absence of high winds, drives the ice. The resultant stress exerted on the ocean by the ice and the resultant Ekman pumping are reversed, without any change in average wind stress curl. Through these curl reversals, the ice‐ocean stress provides a key feedback in Beaufort Gyre stabilization. This manuscript constitutes one of the first observational studies of ice‐ocean stress inclusive of geostrophic ocean currents, by making use of recently available remote sensing data.

Arctic Ocean surface circulation change should not be viewed as the strength of the anticyclonic Beaufort Gyre. While the Beaufort Gyre is a dominant feature of average Arctic Ocean surface circulation, empirical orthogonal function analysis of dynamic height (1950-1989) and satellite altimetry-derived dynamic ocean topography (2004-2019) show the primary pattern of variability in its cyclonic mode is dominated by a depression of the sea surface and cyclonic surface circulation on the Russian side of the Arctic Ocean. Changes in surface circulation after AO maxima in 1989 and 2007-08 and after an AO minimum in 2010, indicate the cyclonic mode is forced by the Arctic Oscillation (AO) with a lag of about one year. Associated with a one standard deviation increase in the average AO starting in the early 1990s, Arctic Ocean surface circulation underwent a cyclonic shift evidenced by increased spatial-average vorticity. Under increased AO, the cyclonic mode complex also includes increased export of sea ice and near-surface freshwater, a changed path of Eurasian runoff, a freshened Beaufort Sea, and weakened cold halocline layer that insulates sea ice from Atlantic water heat, an impact compounded by increased Atlantic Water inflow and cyclonic circulation at depth. The cyclonic mode’s connection with the AO is important because the AO is a major global scale climate index predicted to increase with global warming. Given the present bias in concentration of in situ measurements in the Beaufort Gyre and Transpolar Drift, a coordinated effort should be made to better observe the cyclonic mode.

No abstract

This study compares a continuous injusion technique with inter

Mechanical test lung and artificial trachea simulations may provide useful information on the interaction of HFOV with altered lung mechanics and may contribute to the formulation of HFOV clinical strategies. Important limitations of these models include absence of gas exchange, histologic and biologic markers, or hemodynamic data.

Objectives Transcranial Doppler sonography allows for the estimation of blood flow velocity, whose maximum value, especially at systole, is often of clinical interest. Given that observed values of flow velocity are subject to noise, a useful notion of “maximum” requires a criterion for separating the signal from the noise. All commonly used criteria produce a point estimate (ie, a single value) of maximum flow velocity at any time and therefore convey no information on the distribution or uncertainty of flow velocity. This limitation has clinical consequences especially for patients in vasospasm, whose largest flow velocities can be difficult to measure. Therefore, a method for estimating flow velocity and its uncertainty is desirable. Methods A gaussian mixture model is used to separate the noise from the signal distribution. The time series of a given percentile of the latter, then, provides a flow velocity envelope. This means of estimating the flow velocity envelope naturally allows for displaying several percentiles (eg, 95th and 99th), thereby conveying uncertainty in the highest flow velocity. Results Such envelopes were computed for 59 patients and were shown to provide reasonable and useful estimates of the largest flow velocities compared to a standard algorithm. Moreover, we found that the commonly used envelope was generally consistent with the 90th percentile of the signal distribution derived via the gaussian mixture model. Conclusions Separating the observed distribution of flow velocity into a noise component and a signal component, using a double‐gaussian mixture model, allows for the percentiles of the latter to provide meaningful measures of the largest flow velocities and their uncertainty.

Abstract. Reactive nitrogen (Nr  =  NO, NO2, HONO) and volatile organic carbon emissions from oil and gas extraction activities play a major role in wintertime ground-level ozone exceedance events of up to 140 ppb in the Uintah Basin in eastern Utah. Such events occur only when the ground is snow covered, due to the impacts of snow on the stability and depth of the boundary layer and ultraviolet actinic flux at the surface. Recycling of reactive nitrogen from the photolysis of snow nitrate has been observed in polar and mid-latitude snow, but snow-sourced reactive nitrogen fluxes in mid-latitude regions have not yet been quantified in the field. Here we present vertical profiles of snow nitrate concentration and nitrogen isotopes (δ15N) collected during the Uintah Basin Winter Ozone Study 2014 (UBWOS 2014), along with observations of insoluble light-absorbing impurities, radiation equivalent mean ice grain radii, and snow density that determine snow optical properties. We use the snow optical properties and nitrate concentrations to calculate ultraviolet actinic flux in snow and the production of Nr from the photolysis of snow nitrate. The observed δ15N(NO3−) is used to constrain modeled fractional loss of snow nitrate in a snow chemistry column model, and thus the source of Nr to the overlying boundary layer. Snow-surface δ15N(NO3−) measurements range from −5 to 10 ‰ and suggest that the local nitrate burden in the Uintah Basin is dominated by primary emissions from anthropogenic sources, except during fresh snowfall events, where remote NOx sources from beyond the basin are dominant. Modeled daily averaged snow-sourced Nr fluxes range from 5.6 to 71  ×  107 molec cm−2 s−1 over the course of the field campaign, with a maximum noontime value of 3.1  ×  109 molec cm−2 s−1. The top-down emission estimate of primary, anthropogenic NOx in Uintah and Duchesne counties is at least 300 times higher than the estimated snow NOx emissions presented in this study. Our results suggest that snow-sourced reactive nitrogen fluxes are minor contributors to the Nr boundary layer budget in the highly polluted Uintah Basin boundary layer during winter 2014.