Nováková J., D. Daňová, k. Strišková, R. Hromada, H. Mičková, M. Rabišková: Zinc and Cadmium Toxicity Using a Biotest with Artemia franciscana. acta vet. Brno 2007, 76: 635-642. of the various toxic elements heavy metals, particularly cadmium, lead, mercury and zinc, occur frequently in the environment due to their relatively high industrial use. While the toxicity of individual substances is usually well known, information about their mutual interactions is relatively scarce. in animal experiments the prevailing trend is to substitute higher vertebrates with biotests of the 2 nd generation. our experiment focused on observation of the effect of combinations of ZnSo 4 .7H 2 o and CdCl 2 .2H 2 o on lethality to Artemia franciscana. The aim of the study was to observe the synergistic or antagonistic effects of these two metals.depending on concentration, cadmium may increase or decrease the toxicity of zinc. at higher concentrations of CdCl 2 .2H 2 o exceeding 100 mg·l -1 one can observe obvious synergistic toxic effects of both the substances. our observations allowed us to conclude that the use of optimum, relatively low concentrations of cadmium (up to 50 mg·l -1 CdCl 2 .2H 2 o) results in a significant decrease in lethality to Artemia franciscana caused by ZnSo 4 .7H 2 o at concentrations of 50, 100 a 250 mg·l -1 .
The aim of the study was to observe the effect of ionizing radiation and cadmium chloride on glucose metabolism in broiler chickens. The experiment was conducted on 28-day-old chickens divided into four groups (A, B, C and D). The first group (A) served as control, groups 2 (B) and 3 (C) were irradiated with a single, whole body dose of gamma rays (3 Gy, input 1.14 Gy·min -1 ) and group 3 (C) was administered a water solution of CdCl 2 intraperitoneally at a dose of 6 mg·kg -1 body weight. Group 4 (D) was administered a water solution of CdCl 2 intraperitoneally at the same dose as group 3 but chickens of this group were not irradiated with gamma rays. The serum glucose concentration in the chickens that were irradiated and administered CdCl 2 solution (C) was decreased significantly (p < 0.05) on days 7, 14 and 21 (p < 0.01) of the experiment compared to control (A). The serum glucose concentration in the chickens administered only CdCl 2 (D) was decreased significantly on day 7 compared to control (A). No significant changes in serum glucose concentrations were observed in the remaining group. The results of our experiment indicate that a combined influence of ionizing radiation and administered cadmium chloride resulted in a significant decrease in serum glucose concentration and the influence was more evident than that caused either by cadmium chloride or irradiation alone. The changes in serum glucose concentration observed on days 7 and 14 in gamma-irradiated chickens were lower than those induced only by administration of cadmium chloride.
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