298 4-5%. The early detection of high malignant transformation in OPMD patients is very import. Methods: Paired oral cancer/OPMD surgical specimens were obtained. Gene analysis of exomes was done by next generation sequencing, (NGS). Results: The gene mutation rate was increased in the progression of OPMD to oral cancer. The chromosome 4 and 17 had more mutations in oral cancer specimens. Positive correlation of gene mutation and malignant transformation of OPMD was found. Conclusion: Gene mutation was increased in the transformation of OPMD to oral cancer. Our study might be useful to develop chemical prevention agent to prevent malignant transformation in oral pre-cancer lesions.

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