Clinicopathological characteristics and outcomes of squamous cell carcinoma of the tongue in different age groups

Abstract

298 4-5%. The early detection of high malignant transformation in OPMD patients is very import. Methods: Paired oral cancer/OPMD surgical specimens were obtained. Gene analysis of exomes was done by next generation sequencing, (NGS). Results: The gene mutation rate was increased in the progression of OPMD to oral cancer. The chromosome 4 and 17 had more mutations in oral cancer specimens. Positive correlation of gene mutation and malignant transformation of OPMD was found. Conclusion: Gene mutation was increased in the transformation of OPMD to oral cancer. Our study might be useful to develop chemical prevention agent to prevent malignant transformation in oral pre-cancer lesions.

Oral tongue squamous cell carcinoma survival as stratified by age and sex: A surveillance, epidemiology, and end results analysis

“…18 Although we were unable to determine smoking status of our patient population, previous reports have shown that smoking is an important prognostic factor in patients with OTSCC. 15,16 In contrast with the study by Soudry et al, which reported significantly higher percentages of advanced TNM classification among young patients with OTSCC, 17 we found that young patients had decreased metastatic lymph node disease compared to older patients. This may account for our finding of increased survival rates in younger patients.…”

“…9,14,15 An added advantage of our study is the statistical power to compute DSS in addition to OS, an important metric that has not been performed in prior studies. Younger patients were also more likely to receive multimodality therapy, a finding corroborated by Zhang et al, 16 suggesting that clinicians may be more inclined to aggressively treat OTSCC in younger patients.…”

“…This concurs with the findings of Zhang et al and others. 16,19,20 Interestingly, although poorly differentiated tumors were associated with poor survival in older patients, this was not the case in the young cohort. This finding contrasts the study by Fang et al, which found tumor grade to be the most important prognostic factor in survival of young patients with OTSCC.…”

“…This is yet another interesting finding that warrants further study, especially in the context of the debate in clinical circles as to whether OTSCC in young patients represents a separate clinical entity with distinctive etiologic factors. 8,16,21 Investigating the etiologies of OTSCC in young patients may provide clinicians with not only more informed pretreatment planning to improve survival rates, but also an approach to curb OTSCC's rising incidence.…”

Treponema denticola chymotrypsin‐like proteinase is present in early‐stage mobile tongue squamous cell carcinoma and related to the clinicopathological features

“…Vora et al 28 Previous study has reported that younger patients with MTSCC tend to have higher recurrence rate and highest recurrence death rate. 30 However, the underlying factors that determine this difference between young and old patients are largely unknown. Therefore, more concern should be paid to the MTSCC in younger patients to understand better the possible factors behind these tumours and find better prognostic markers in this patients group.…”