Community-acquired pneumonia is an acute inflammation of the pulmonary parenchyma caused by bacterial infection. . The main therapy for community-acquired pneumonia is the use of antibiotics. Inappropriate antibiotics can lead to bacterial resistance. The study aims to determine Appropriateness of antibiotics prescribing using the method Gyssens with clinical improvement. This study is a retrospective analytic cohort descriptive. Data was collected retrospectively based on medical records of inpatients at one of the hospital in Yogyakarta for the January-December 2019 period based. The accuracy of empiric antibiotic prescription using the Gyssens method. The clinical improvements observed were leukocyte count, temperature, respiratory rate. This study was analyzed using the chi square method. The results showed 41 patients met the inclusion and exclusion criteria, male gender (51.2%), age> 60 years 68.3%, the average length of stay was five days. Ceftriaksone is a commonly used antibiotic. Evaluation prescribing appropriateness based on the Gyssens method of 52 antibiotic regimens. appropriate antibiotic prescribing (13.5%) and inappropriate (86.5%). The correlation between appropriateness of antibiotics prescribing with clinical improvement leukocytes count, respiratory rate and temperature did not significant (p> 0.05). There was no correlation between the accurasy of antibiotics prescribing based on the Gyssens method with clinical improvement.
The use of antibiotics as the main standard of pneumonia treatment is usually prescribed in high quantities. Inappropriate selection of antibiotics can lead to bacterial resistance, treatment failure, and the emergence of DRPs (Drug-Related Problems). This study aims to determine the suitability of antibiotic prescribing using the PCNE method and to determine the correlation between the suitability of antibiotic prescribing and clinical response. This study was analyzed using a retrospective analytic cohort study method with data collection of adult Community-Acquired Pneumonia patients medical record, who were hospitalized in private hospital in Yogyakarta from January to December 2019. In addition, this study also assessed antibiotic prescribing according to the PCNE V8.02 method toward patients' clinical response (the number of leukocyte, temperature, and respiratory rate) after take the antibiotics. The correlation according to antibiotic prescribing analyzed according to chi-square method. The results showed that a total of 52 antibiotic regimens obtained in the evaluation of antibiotic prescribing according to the PCNE method were 21.5% suitable and 78.8% not suitable. Thus, the results of the correlation test for the accuracy of antibiotic prescribing and clinical response to the number of leukocytes showed a significant relationship (p<0.05). However in this study, none significant correlation was found in antibiotic prescription and clinical response in terms of temperature and respiratory rate (p<0.05).
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