Correlation Between Appropriateness Prescribing Antibiotics and Clinical Improvement on Hospitalized Patients with Community Acquired Pneumonia Based on The Gyssens Method

Abstract

Community-acquired pneumonia is an acute inflammation of the pulmonary parenchyma caused by bacterial infection. . The main therapy for community-acquired pneumonia is the use of antibiotics. Inappropriate antibiotics can lead to bacterial resistance. The study aims to determine Appropriateness of antibiotics prescribing using the method Gyssens with clinical improvement. This study is a retrospective analytic cohort descriptive. Data was collected retrospectively based on medical records of inpatients at one of the hospital in Yogyakarta for the January-December 2019 period based. The accuracy of empiric antibiotic prescription using the Gyssens method. The clinical improvements observed were leukocyte count, temperature, respiratory rate. This study was analyzed using the chi square method. The results showed 41 patients met the inclusion and exclusion criteria, male gender (51.2%), age> 60 years 68.3%, the average length of stay was five days. Ceftriaksone is a commonly used antibiotic. Evaluation prescribing appropriateness based on the Gyssens method of 52 antibiotic regimens. appropriate antibiotic prescribing (13.5%) and inappropriate (86.5%). The correlation between appropriateness of antibiotics prescribing with clinical improvement leukocytes count, respiratory rate and temperature did not significant (p> 0.05). There was no correlation between the accurasy of antibiotics prescribing based on the Gyssens method with clinical improvement.

Evaluation of the use of antibiotics using the anatomical therapeutic chemical/defined daily dose and Gyssens methods in pneumonia patients at a tertiary care general hospital in Medan

“…Ceftriaxone exhibits a wide range of antibacterial activity against both gram-positive and gram-negative pathogens. 6 When compared to other preparations in the cephalosporin class, ceftriaxone exhibits significant efficacy against gram-positive pathogens like Streptococcus sp. and Streptococcus pneumoniae, as well as gram-negative organisms such as Branhamella catarhalis, Escherichia coli, Proteus sp., and Haemophilus influenza.…”

Analysis of Adverse Drug Reactions (ADRs) Using Antibiotic for Community Acquired Penumonia (CAP) Disease of Toddler

“…Hal ini serupa dengan penelitian su et al (2021) menunjukkan bahwa hubungan penggunaan antibiotik terhadap outcome pasien CAP terlihat bahwa nilai p yang didapat sebesar 0,750 karena nilai p>0,05 maka dapat disimpulkan bahwa tidak ada hubungan yang signifikan antara penggunaan antibiotik empiris terhadap outcome terapi pasien CAP, dikarenakan penggunaan antibiotik sudah rasional(Feri et al, 2021). Selain itu, penelitian yang dilakukan olehUlfa et al (2021), menunjukkan Uji hubungan ketepatan peresepan antibiotik dengan perbaikan klinis (outcome) tidak didapatkan adanya hubungan yang bermakna (p> 0, 05). Tidak didapatkan adanya hubungan bermakna antara ketepatan peresepan antibiotik berdasarkan metode Gyssens dengan perbaikan klinis karena ada antibiotik lain yang spektrumnya lebih sempit.…”

“…Tidak didapatkan adanya hubungan bermakna antara ketepatan peresepan antibiotik berdasarkan metode Gyssens dengan perbaikan klinis karena ada antibiotik lain yang spektrumnya lebih sempit. Pemilihan antibiotik yang sempit dapat mencegah terjadinya efek samping antibiotik(Ulfa et al, 2021).Pada penelitian yang dilakukan oleh Insan (2023). Hasil yang diperoleh dari uji chi-square yang dilakukan adalah tidak terdapat perbedaan yang bermakna (p>0,05) antara kelompok antibiotik tepat dan tidak tepat terhadap outcome pasien pneumonia anak(Insan et al, 2023).…”