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Background Takotsubo syndrome is a clinical syndrome characterized by an acute and transient left ventricular systolic dysfunction related to an emotional or physical stressful event. Case presentation During the Covid‐19 pandemic, five cases of Takotsubo syndrome in hospitalized, mechanically ventilated patients due critical SARS‐CoV‐2 infection have been identified at our institution. Here we present the electrocardiographic, echocardiographic and angiographic characteristics of this case series. All cases were initially suspected by echocardiography performed due an abnormal electrocardiogram, troponin elevation or clinical deterioration. Conclusion A high index of suspicion should be sought to identify Takotsubo syndrome and other cardiac complications associated with SARS‐CoV‐2 infection.

This group of patients with complex coronary lesions has a high prevalence of coronary risk factors, which could represent a worse prognosis.

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