A model for the transmission of dengue fever with variable human population size is analyzed. We find three threshold parameters which govern the existence of the endemic proportion equilibrium, the increase of the human population size, and the behaviour of the total number of human infectives. We prove the global asymptotic stability of the equilibrium points using the theory of competitive systems, compound matrices, and the center manifold theorem.
We formulate a non-linear system of differential equations that models the dynamics of dengue fever. This disease is produced by any of the four serotypes of dengue arbovirus. Each serotype produces permanent immunity to it, but only a certain degree of cross-immunity to heterologous serotypes. In our model we consider the relation between two serotypes. Our interest is to analyze the factors that allow the invasion and persistence of different serotypes in the human population. Analysis of the model reveals the existence of four equilibrium points, which belong to the region of biological interest. One of the equilibrium points corresponds to the disease-free state, the other three equilibria correspond to the two states where just one serotype is present, and the state where both serotypes coexist, respectively. We discuss conditions for the asymptotic stability of equilibria, supported by analytical and numerical methods. We find that coexistence of both serotypes is possible for a large range of parameters.
In this work we formulate and analyze a mathematical model for the transmission of West Nile Virus (WNV) infection between vector (mosquito) and avian population. We find the Basic Reproductive Number R0 in terms of measurable epidemiological and demographic parameters. R0 is the threshold condition that determines the dynamics of WNV infection: if R0< or =1 the disease fades out, and for R0 >1 the disease remains endemic. Using experimental and field data we estimate R0 for several species of birds. Numerical simulations of the temporal course of the infected bird proportion show damped oscillations approaching the endemic value.
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