RESUMO:Nesta pesquisa foi avaliada a atividade antimicrobiana e a capacidade de inibição da síntese de glucano in vitro do extrato da casca do fruto da romã (Punica granatum Linn.) sobre linhagens bacterianas de Streptococcus mitis, Streptococcus mutans, Streptococcus sanguis, Streptococcus sobrinus e Lactobacillus casei. Os ensaios foram realizados pelas técnicas de ágar-difusão em placas para determinação da Concentração Inibitória Mínima (CIM) e técnica dos tubos inclinados para determinação da Concentração Inibitória Mínima de Aderência (CIMA) ao vidro, na presença de 5% de sacarose. Os mesmos procedimentos foram realizados com a clorexidina à 0,12%. As CIMs (mg/mL) do extrato da P. granatum frente ao S. mitis, S. mutans, S. sanguis, S. sobrinus e L. casei foram 1:32, 1:8, 1:8, 1:512, e 1:128, respectivamente. Para as CIMAs o extrato da P. granatum mostrou resultados melhores que a clorexidina, exceto para o S. mutans com achados semelhantes na diluição de 1:256. Os resultados mostram a potencialidade da P. granatum na inibição do crescimento bacteriano e síntese de glucano representada pela aderência ao vidro, sugerindo o emprego do extrato da romã, como meio alternativo, no controle desses microrganismos na formação do biofi lme.Unitermos: Punica granatum, atividade antimicrobiana, efeito antiaderente, biofi lme dental, Streptococcus.ABSTRACT: "In vitro antibacterial and antiadherence effect of the extract of the Punica granatum Linn. upon dental biofi lm microrganisms". In this study was evaluated the in vitro antibacterial activity and the inhibition of glucan sintesis of the fruit bark of Punica granatum Linn extract upon the following dental biofi lm bacteria: Streptococcus mitis, Streptococcus mutans, Streptococcus sanguis, Streptococcus sobrinus and Lactobacillus casei. The tests were carried out by inundation tecniques in Petri dishes to determine the Minimum Inhibitory Concentration (MIC) and inclined tubes techniques to determine the Minimum Inhibitory Concentration of Adherence to glass (MICA) at the presence of 5% sucrose. Tests with gluconate of chlorexidine (0.12%) were performed as controls. MICs of the P granatum extract dilutions (mg/mL) against S. mitis, S. mutans, S. sanguis, S. sobrinus e L. casei were 1:32, 1:8, 1:8, 1:512, and 1:128 respectively. For MICAs the P. granatum showed better results than chlorexidine, except for S. mutans with both substances showing similar results of 1:256. It can be concluded that the extract of the P. granatum has the potential to inhibit oral bacterial growth and glucan sintesis. The extract of the Punica granatum might be used as an effective antibacterial alternative agent against oral biofi lm bacteria.
RESUMO Objetivo:A Universidade tem sua base na indissociabilidade entre Ensino, Pesquisa e Extensão. Logo, objetivouse investigar o nível de conhecimento sobre os programas de pesquisa/extensão, assim como traçar um perfil das principais áreas envolvidas em projetos no Centro de Ciências Biológicas e da Saúde na Universidade Federal de Campina Grande (UFCG/CCBS) com os discentes do 1º a 8º períodos do curso de Medicina. Metodologia: Realizou-se um estudo descritivo quantitativo de março a abril de 2012. A coleta de dados foi realizada através de questionários versando sobre a participação, o interesse e problemas para ingressar em programas de iniciação científica e extensão. Resultados: Dos 149 estudantes, 18,1% responderam que a falta de tempo foi o principal problema para o ingresso nos programas. A participação de alunos nos programas aumenta ao decorrer do curso enquanto o interesse em participar se faz presente desde os primeiros períodos. 91,4% acreditam que esses projetos contribuem para a sua formação profissional e aponta-se o enriquecimento do currículo como principal foco dos alunos engajados. Em relação às áreas de atuação evidencia-se Ginecologia/Obstetrícia (29,41%) como eixo preferencial para pesquisa e Saúde Coletiva (22,72%) para extensão. Conclusão: Percebe-se que existe uma deficiência em relação ao acesso dos discentes do curso de Medicina às atividades de iniciação científica e extensão. Maior sensibilização e acesso à informação são efetivos no envolvimento de graduandos em atividades extracurriculares. DESCRITORESMedicina. Relações Comunidade-instituição. Projetos de Pesquisa. Educação de Graduação em Medicina. ABSTRACTObjective: University has its basis in the inseparability of Teaching, Research and Extension. Given this, it was aimed to investigate the level of knowledge on research/extension programs, as well as to profile the key areas involved in projects at the Center for Biological and Health Sciences, Federal University of Campina Grande (UFCG / CCBS), with students from the 1 st to 8 th periods of medical school. Material and Methods:We carried out a quantitative descriptive study from March to April 2012. Data collection was conducted by means of questionnaires about participation, interest and problems to join undergraduate research and extension programs. Results: Of the 149 students, 18.1% referred to lack of time as the main problem for entering into the programs. The participation of students in the programs increases during the course, while interest in participating has been present since the earliest periods. A total of 91.4% believe that these projects contribute to their professional training and point curriculum enrichment as the main focus for them to be engaged. Regarding areas of expertise, gynecology / obstetrics (29.41%) are the preferred axis for research as public health (22.72%) is for extension. Conclusion: It is noticed that there is a deficiency in relation to the access of medical students to research and extension activities. Increased awareness and acce...
The marked expression of these matrilysins suggests their role in the process of tissue remodeling and growth in the studied tumors, but it does not relate to the their distinct patterns of aggressiveness.
The health of the study participants and their unborn children is at risk due to the inappropriate use of medicinal plants.
This study aimed to show the comprehension that patients bearing vitiligo have over their condition, also assessing the association with their health and disease concepts. It is a qualitative research with descriptive and exploratory purposes, carried out from an epidemiological survey throughout the years of 2010-2013, with records from a dermatology outpatient care sector of a seminal hospital located in the city of Campina Grande – Paraíba, Brazil. It was identified that from the 832 existing records, 13 were of vitiligo patients and, from them, eight agreed to be part of this study, answering a semi-structured questionnaire. Data examination was made using the Thematic Content Analysis technique, identifying four categories. Results indicated that the process of being stricken with the disease is directly related to social practices that target the “stained” subject, over whom vitiligo has imprinted its patches.
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