BackgroundAccurate and early prognosis of disease is essential to clinical decision making, particularly in diseases, such as HCC, that are typically diagnosed at a late stage in the course of disease and therefore carry a poor prognosis. CDCA5 is a cell cycle regulatory protein that has shown prognostic value in several cancers.MethodsWe retrospectively evaluated 178 patients with HCC treated with curative liver resection between September 2009 and September 2012 at Nanchong Central Hospital in Nanchong, Sichuan Province, China. Patients were screened for their CDCA5 expression levels and assigned to either the high or low expression group. Patient demographics, comorbidities, clinicopathologic data, such as tumor microvascular invasion status and size, and long-term outcomes were compared between the two groups. The effect of CDCA5 on the proliferation of liver cancer cells was analyzed using in vitro and in vivo assays.ResultsThe present study found that increased CDCA5 expression was associated with increased tumor diameter and microvascular invasion in HCC. It was also found that CDCA5 overexpression may be associated with liver cancer cells. Additionally, this study confirmed that CDCA5 expression was increased in HCC tissue versus normal liver tissue, that CDCA5 expression was associated with decreased survival and that CDCA5 knockdown using shRNA led to cell cycle arrest in the G2/M phase.ConclusionsThese findings suggest that CDCA5 expression is associated with poor prognosis in patients with hepatocellular carcinoma.
Vascular intrapelvic complications due to total hip arthroplasty failure are uncommon, with less than 30 cases reported in the literature. Herein, we report a case of unusual asymptomatic delayed vascular complication after 10 years from right total hip arthroplasty. A man in mid-50s, with multiple comorbidities including end-stage renal disease. The patient was admitted for the renal transplant surgery. Intraoperatively, right external iliac artery pseudoaneurysm was discovered, which required the transplantation to be done on the left side. After recovery from the renal transplant surgery, the patient underwent resection of the right external iliac artery pseudoaneurysm with primary anastomosis by vascular surgery, with resection of the migrated screw by orthopaedic surgery.
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