A highly selective and high yield synthesis for the production of calix [8]arenes in concentrated reaction masses is described. Obtained purities are >98% and yields of >80%, with isolation by simple filtration. The developed approach allows for subsequent "in situ" formation of calix [4]arenes. The syntheses are amenable to large scale manufacturing. Kinetic observations during the formation of calix[4]arenes from calix[8]arenes are included. Furthermore, details related to "soluble" calix[4]arene are described.
Owing to vicinal coupling, a doublet is observed for Ha, Hh, or Hh' (Fig. 2), in the region of the aromatic protons and a doublet of a doublet is observed for H"', which appears as a triplet in the spectrum. Three signals are observed for the C,, and the D,, isomers, (two doublets, one doublet of a doublet) for the three aromatic protons H", Ha' and Hb or Hh'. It is -6
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.