One‐step ring‐annulation of 5‐substituted 2‐amino‐2‐oxazolines with diethyl ethoxymethy‐lenemalonate yielded 2‐substituted 6‐carboethoxy‐2,3‐dihydro‐5H‐oxazolo[3,2‐a]pyrimidin‐5‐ones. Under the same conditions 2‐substituted 6‐cyano‐2,3‐dihydro‐5H‐oxazolo[3,2‐a]‐pyrimidin‐5‐ones and the corresponding 2‐ethyl(methylenecyanoacetate)‐2‐iminooxazo‐lidines were obtained from ethyl ethoxymethylenecyanoacetate. Some of these compounds were evaluated in mice for antiparasitic activity.
Some N‐phenyl(thio)carbamoyl‐2‐iminooxazolidines and 2‐oxazolidinones were synthesized via 2‐amino‐2‐oxazolines and tested as antiviral and antitumour agents.
Moderate antitumour activity was found for the 5‐(1‐phenyl‐4‐piperazinyl)methyl substituted compounds.
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