Synthesis, Antitumour and Anti-HIV Screening of Oxazolidines and Oxazolidinones Derivatives

Abstract

Some N‐phenyl(thio)carbamoyl‐2‐iminooxazolidines and 2‐oxazolidinones were synthesized via 2‐amino‐2‐oxazolines and tested as antiviral and antitumour agents. Moderate antitumour activity was found for the 5‐(1‐phenyl‐4‐piperazinyl)methyl substituted compounds.

Synthesis and pharmacological evaluation of 5-dialkylaminomethyl-2-amino-2-oxazolines as H1-antagonists

“…For several years we have focused our attention mainly on the chemistry of 2amino-2-oxazolines (Jarry et al 1986, Bosc et al 1992. Recently, we reported the synthesis of 5-[(1-aryl-4-piperazinyl)methyl]-2-amino-2-oxazolines useful either as synthons (Chaimbault et al 1999, Forfar et al 1999 or as precursors of potentially active ring-opened compounds (Bosc & Jarry 1998). 5-Aryl-2-amino-2-oxazolines have been widely investigated for pharmaceutical uses.…”