In Brazil, a scoring system was adopted to diagnose tuberculosis in childhood. This study determined the accuracy in diagnosing tuberculosis in children with either a negative smear or with no smear or culture conducted in a reference center in João Pessoa Paraíba - Brazil. It is a phase III validation study, using a cross-section design. The study population consisted of 167 patients attending the outpatient clinics suspected of having tuberculosis. The reference standard for the diagnosis of tuberculosis was a blind and independent review of the medical records, radiology and tuberculin test by two experts. Of the 167 patients, 60 were considered to have tuberculosis (by the reference standard diagnostics). The results for the scoring system with the cut-off of 30 points were: sensitivity 78.57% (95%-CI: 65.56-88.41%), specificity 69.16% (95%-CI: 59.50-77.73%), positive predictive value (PPV): 57.14% (95%-CI: 45.35-68.37%), negative predictive value (NPV): 86.05% (95%-CI: 76.89-92.58%), likelihood ratio (+): 2,55, pre-test probability: 34.36%, and post-test probability (+): 57.14%. This supports the current recommendation for the use of this scoring system in Brazil and similar sites with the cut-off of 30 points. However, as the discriminatory power of the point scoring system may vary across settings, it would be advisable to replicate this phase III study in different settings.
Revista de Nutrição Rev. Nutr. 2018;31(2):211-220 25(OH)D AND HB LEVEL IN PATIENTS WITH CF ABILITY 211 http://dx.Article based on the master thesis of MLC ASSIS, entitled "Prevalência do Polimorfismo FOKI do Gene VDR em Pacientes Portadores de Fibrose Cística: Associação com Valores Hematológicos e 25-Hidroxivitamina D". Universidade Federal da Paraíba; 2017. Como citar este artigo/How to cite this article Assis MLC, Cartaxo CGB, Costa MJC, Queiroz DJM, Persuhn DC, Gonçalves MCR. Association between hematological profile and serum 25-hydroxyvitamin D levels and FokI polymorphism in individuals with cystic fibrosis. Rev Nutr. 2018;31(2):211-20. http://dx.
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