Skin wounds are usually accompanied
by bacterial infections and
inflammations, leading to delayed wound healing, which remain a great
challenge in clinical treatment. Therefore, it is of great significance
to develop wound dressings that inhibit bacterial infections to accelerate
wound healing. Herein, we reported the fabrication of inclusion complex
(a β-cyclodextrin covalent organic framework loaded with enrofloxacin
and flunixin meglumine)-incorporated electrospun thermoplastic polyurethane
fibers (named ENR-FM-COF-TPU) via electrospinning. The obtained ENR-FM-COF-TPU
fibrous membrane exhibited excellent physicochemical and biological
properties such as uniform and stable morphology, proper hydrophobicity,
good water uptake capacity, and admirable biocompatibility, which
showed perfect behavior as a wound dressing. In addition, the ENR-FM-COF-TPU
membrane achieved a sustained drug release of enrofloxacin and flunixin
meglumine and displayed powerful antibacterial activity against Staphylococcus aureus and Escherichia coli with 99% inhibitory efficiency for 50 h. More importantly, the wound
healing therapy effect was investigated using a full-thickness skin
defect model of mice. It suggested that the ENR-FM-COF-TPU membrane
could significantly accelerate and enhance wound healing through downregulating
inflammatory cytokines (IL-1β and TNF-α) and increasing
the expression of growth factors (VEGF and EGF). Due to its excellent
properties, the ENR-FM-COF-TPU membrane may have promising potential
in wound healing applications.
Wound healing process is usually accompanied by infection and the wound dressing loaded with antibiotics is usually used to treat skin wound. However, the intensive use of antibiotics may lead to development of resistance and the antibiotic resistance has become a major global problem. Finding new wound dressing with sustained antibacterial property to overcome the problem of resistance is one of clinical challenge. In this work, phenolic acids in Spenceria ramalana Trimen and sliver nanoparticle incorporated thermoplastic polyurethane nanofibrous membrane (TPU/AgNPs/TPA) are fabricated via electrospinning. The TPU/AgNPs/TPA membrane exhibits excellent physicochemical properties with uniform morphology, good mechanical capacity, and appropriate hydrophilia providing suitable environment for wound healing. Moreover, the TPU/AgNPs/TPA membrane shows mild antioxidant property and exhibits continuous antibacterial activity against Staphylococcus aureus and Escherichia coli especially against drug‐resistant E. coli. The antibacterial efficiency is as high as 99% lasting for 36 h. Furthermore, the TPU/AgNPs/TPA membrane used as wound dressing can accelerate wound healing through downregulating TNF‐α and IL‐1β and upregulating vascular endothelial growth factor and epidermal growth factor. Therefore, the TPU/AgNPs/TPA membrane presented in this work with good antibacterial activity is an excellent wound dressing and has great potential in wound healing applications to overcome the problem of resistance.
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