Cyclodextrin metal-organic framework as vaccine adjuvants enhances immune responses

Li, Congcong; Chen, Chaoxi; Wei, Yucai; Tan, Min; Zhai, Shuo; Zhao, Juebo; Wang, Lu; Dai, Tao

doi:10.1080/10717544.2021.2012306

Cited by 14 publications

(18 citation statements)

References 32 publications

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“…Notably, a similar method was used to prepare cyclodextrin metal-organic framework as vaccine adjuvants. 138 In 2020 Zhang and colleagues 139 developed a facile method for the synthesis of NanoSheets-MOFs (2D-nanosheet cyclodextrins-based metal-organic frameworks) based on a one-pot reaction involving g-CD and K 2 CO 3 in aqueous medium. K 2 CO 3 and g-CD were dissolved in distilled water aided by heating the reaction mixture at 70 1C.…”

Section: Green Synthesis Of Cd-mofsmentioning

confidence: 99%

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Scattolin,

Tonon,

Botter

et al. 2024

J. Mater. Chem. B

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Section: Green Synthesis Of Cd-mofsmentioning

confidence: 99%

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Scattolin,

Tonon,

Botter

et al. 2024

J. Mater. Chem. B

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“…[84] Besides ZIF-8 which is commonly used, other kinds of MOFs have also been developed as vaccine vehicles including MIL-101-Fe-NH 2 , [49] amino-functionalized zirconium-based MOF (UiO-AM), [85] hexahistidine metal assembly (HmA), [86] and 𝛾-cyclodextrin MOF. [87] (Table 1)…”

Section: Vaccinementioning

confidence: 99%

Advances in Immunomodulatory MOFs for Biomedical Applications

Zhang,

Chen,

Zhu

et al. 2023

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Given the crucial role of immune system in the occurrence and progression of various diseases such as cancer, wound healing, bone defect, and inflammation‐related diseases, immunomodulation is recognized as a potential solution for treatment of these diseases. Immunomodulation includes both immunosuppression in hyperactive immune conditions and immune activation in hypoactive conditions. For these purposes, metal–organic frameworks (MOFs) are investigated to modulate immune responses either by their own bioactivities or by delivering immunomodulatory agents due to their excellent biodegradability and high delivery capacity. This review starts with an overview of the synthesis strategies of immunomodulatory MOFs, followed by a summarization on the latest applications of immunomodulatory MOFs in cancer immunomodulatory, wound healing, inflammatory disease, and bone tissue engineering. A variety of design considerations, in order to optimize immunomodulatory properties and efficacy of MOFs, is also involved. Last, the challenges and perspectives of future research, which are expected to provide researchers with new insight into the design and application of immunomodulatory MOFs, are discussed.

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“…[ 176 ] In order to avoid the toxicity caused by the introduction of heavy ions and toxic solvents during MOF synthesis, a green preparation process for novel MOFs has been developed. [ 177 ] Cyclodextrin MOFs (CD‐MOFs) have been prepared as adjuvants by green synthesis to enhance immune responses. [ 177 ] CD‐MOFs display excellent biosafety in various animals, including chickens, mice, and goats, whereas they have a significant hemolytic effect on rabbits.…”

Section: Biosafety Risks Associated With Nanoparticles Use In Animalsmentioning

confidence: 99%

“…[ 177 ] Cyclodextrin MOFs (CD‐MOFs) have been prepared as adjuvants by green synthesis to enhance immune responses. [ 177 ] CD‐MOFs display excellent biosafety in various animals, including chickens, mice, and goats, whereas they have a significant hemolytic effect on rabbits. LNPs have been used in mRNA vaccines, and clinical studies have shown low reactogenicity and good tolerability.…”

Section: Biosafety Risks Associated With Nanoparticles Use In Animalsmentioning

confidence: 99%

Advances of Nanotechnology Toward Vaccine Development Against Animal Infectious Diseases

Wang

Gao

Wang

et al. 2023

Adv Funct Materials

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Vaccines are the most effective means of controlling infectious diseases. Increasingly epidemics have driven the development of vaccines for human use. However, insufficient attention has been paid to preventing animal epidemics. The spread of animal epidemics directly affects food and nutritional safety, the economy, and outbreaks of zoonotic diseases, which can eventually threaten human health. Reducing safety risks, saving production costs, adapting to mass vaccination, and improving immunogenicity are important that must be considered in animal vaccines. Nanotechnology in vaccine development provides unique advantages in meeting these challenges, both at in vitro preparation and in vivo immune response levels. In terms of in vitro vaccine formulation, nanoparticles offer the possibility to provide multiple antigen display sites, maintain antigen conformation, and improve vaccine stability, which facilitates the development of vaccines with enhanced immunogenicity and thermal stability. In terms of in vivo vaccine‐induced immunity, nanoparticles show superior immunostimulatory activity which facilitates multiple immune response processes, including antigen delivery, cellular uptake, antigen presentation, and lymphocyte activation, thus markedly augmenting vaccine‐mediated immune responses. Herein, the application of nanotechnology to vaccine development and the characteristics of animal vaccines are reviewed, aiming to provide general guidelines for the design of future vaccines against animal infectious diseases and promote harmonious coexistence of humans and animals.

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Cyclodextrin metal-organic framework as vaccine adjuvants enhances immune responses

Cited by 14 publications

References 32 publications

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Advances in Immunomodulatory MOFs for Biomedical Applications

Advances of Nanotechnology Toward Vaccine Development Against Animal Infectious Diseases

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