No abstract

No abstract

Introduction: Multiple Sclerosis is a chronic inflammatory neurodegenerative disease of large magnitude in the world. Method and Goal:To analyze primary studies associating high dose of vitamin D with the prognosis of patients with multiple sclerosis.Results: 9 studies were selected, including 1022 participants. 630 of them were randomized to vitamin D3 supplementation in high dose, 171 in low-dose and 221 receiving placebo. Conclusion:There is evidence that high dose of Vitamin D3 provide immunomodulatory effects in patients with Multiple Sclerosis, showing improvement in the patients' prognosis.