Wearable sweat sensors are emerging as promising platforms for personalized and real-time tracking of evolving health and fitness parameters. While most wearable sweat sensors focus on tracking biomarker concentration profiles, sweat secretion rate is a key metric with broad implications for assessing hydration, cardiac, and neural conditions. Here we present a wearable microfluidic sensor for continuous sweat rate measurement. A discrete impedimetric sensing scheme relying on interdigitated electrodes within a microfluidic sweat collector allows for precise and selective sweat rate measurement across a broad physiological range. Integration of a manually activated pressure pump to expel sweat from the device prevents sensor saturation and enables continuous sweat rate tracking over hours. By enabling broad range and prolonged sweat rate measurement, this platform tackles a key obstacle to realizing meaningful and actionable sweat sensing for applications in exercise physiology and medicine.
Potentiostat-based solutions are widely used as an instrumentation platform for electrochemical and biochemical sensing systems, which are extensively used in areas as diverse as biomedical analysis, food safety and monitoring of environmental pollutants. Biomedical diagnostics is a relatively new application area of these systems, which can allow for in vivo, long-term patient investigation outside of the hospital environment. It is expected that this emerging area will enable physicians to obtain radically new and unique diagnostic information. The development of such an on-chip potentiostat-based sensing system suitable for in vivo biomedical applications is the subject of the present study. The design is realized on a mixed signal silicon breadboard substrate which allows for a low cost and time efficient progression from concept to full integration on CMOS.
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