We investigate a large geodetic data set of interferometric synthetic aperture radar (InSAR) and GPS measurements to determine the source parameters for the three main shocks of the 2016 Central Italy earthquake sequence on 24 August and 26 and 30 October (Mw 6.1, 5.9, and 6.5, respectively). Our preferred model is consistent with the activation of four main coseismic asperities belonging to the SW dipping normal fault system associated with the Mount Gorzano‐Mount Vettore‐Mount Bove alignment. Additional slip, equivalent to a Mw ~ 6.1–6.2 earthquake, on a secondary (1) NE dipping antithetic fault and/or (2) on a WNW dipping low‐angle fault in the hanging wall of the main system is required to better reproduce the complex deformation pattern associated with the greatest seismic event (the Mw 6.5 earthquake). The recognition of ancillary faults involved in the sequence suggests a complex interaction in the activated crustal volume between the main normal faults and the secondary structures and a partitioning of strain release.

We investigate the ground deformation and source geometry of the 2016 Amatrice earthquake (Central Italy) by exploiting ALOS2 and Sentinel‐1 coseismic differential interferometric synthetic aperture radar (DInSAR) measurements. They reveal two NNW‐SSE striking surface deformation lobes, which could be the effect of two distinct faults or the rupture propagation of a single fault. We examine both cases through a single and a double dislocation planar source. Subsequently, we extend our analysis by applying a 3‐D finite elements approach jointly exploiting DInSAR measurements and an independent, structurally constrained, 3‐D fault model. This model is based on a double fault system including the two northern Gorzano and Redentore‐Vettoretto faults (NGF and RVF) which merge into a single WSW dipping fault surface at the hypocentral depth (8 km). The retrieved best fit coseismic surface deformation pattern well supports the exploited structural model. The maximum displacements occur at 5–7 km depth, reaching 90 cm on the RVF footwall and 80 cm on the NGF hanging wall. The von Mises stress field confirms the retrieved seismogenic scenario.

We present an advanced differential synthetic aperture radar (SAR) interferometry (DInSAR) processing chain, based on the Parallel Small BAseline Subset (P-SBAS) technique, for the efficient generation of deformation time series from Sentinel-1 (S-1) interferometric wide (IW) swath SAR data sets. We first discuss an effective solution for the generation of high-quality interferograms, which properly accounts for the peculiarities of the terrain observation with progressive scans (TOPS) acquisition mode used to collect S-1 IW SAR data. These data characteristics are also properly accounted within the developed processing chain, taking full advantage from the burst partitioning. Indeed, such data structure represents a key element in the proposed P-SBAS implementation of the S-1 IW processing chain, whose migration into a cloud computing (CC) environment is also envisaged. An extensive experimental analysis, which allows us to assess the quality of the obtained interferometric products, is presented. To do this, we apply the developed S-1 IW P-SBAS processing chain to the overall archive acquired from descending orbits during the March 2015-April 2017 time span over the whole Italian territory, consisting in 2740 S-1 slices. In particular, the quality of the final results is assessed through a large-scale comparison with the GPS measurements relevant to nearly 500 stations. The mean standard deviation value of the differences between the DInSAR and the GPS time series (projected in the radar line of sight) is less than 0.5 cm, thus

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The regeneration of damaged organs requires that engineered tissues mature when implanted at sites of injury or disease. We have used new analytic techniques to determine the extent of tissue regeneration after treatment of knee injury patients with a novel cartilage tissue engineering therapy and the effect of pre-existing osteoarthritis on the regeneration process. We treated 23 patients, with a mean age of 35.6 years, presenting with knee articular cartilage defects 1.5 cm2 to 11.25 cm2 (mean, 5.0 cm2) in area. Nine of the patients had X-ray evidence of osteoarthritis. Chondrocytes were isolated from healthy cartilage removed at arthroscopy. The cells were cultured for 14 days, seeded onto esterified hyaluronic acid scaffolds (Hyalograft C), and grown for a further 14 days before implantation. A second-look biopsy was taken from each patient after 6 to 30 months (mean, 16 months). After standard histological analysis, uncut tissue was further analyzed using a newly developed biochemical protocol involving digestion with trypsin and specific, quantitative assays for type II collagen, type I collagen, and proteoglycan, as well as mature and immature collagen crosslinks. Cartilage regeneration was observed as early as 11 months after implantation and in 10 out of 23 patients. Tissue regeneration was found even when implants were placed in joints that had already progressed to osteoarthrosis. Cartilage injuries can be effectively repaired using tissue engineering, and osteoarthritis does not inhibit the regeneration process.

We investigate the 24–27 December 2018 eruption of Mount Etna occurred from fissures located on the volcano eastern flank and accompanied by a seismic swarm, which was triggered by the magma intrusion and continued for weeks after the end of the eruption. Moreover, this swarm involved some of the shallow volcano‐tectonic structures located on the Mount Etna flanks and culminated on 26 December with the strongest event (ML 4.8), occurred along the Fiandaca Fault. In this work, we analyze seismological data and Sentinel‐1 Differential Interferometric Synthetic Aperture Radar (DInSAR) measurements, the latter inverted through analytical modeling. Our results suggest that a dike source intruded, promoting the opening of the eruptive fissures fed by a shallower dike. Moreover, our findings indicate that the activation of faults in different sectors of the volcano may be considered as a response to accommodate the deformations induced by the magma volumes injection.

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