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Paraparesis and paraplegia are common conditions in dogs, most often caused by a disc herniation in the thoracolumbar spinal segments (T3-L3), which is a neurological emergency. Surgical decompression should be performed as soon as possible when spinal compression is revealed by myelography, computed tomography, or magnetic resonance imaging. Mesenchymal stem-cell therapy is a promising adjunct treatment for spinal cord injury. This study sought to compare the effects of surgical decompression alone and combined with an allogeneic transplantation of canine adipose tissue-derived mesenchymal stem cells (cAd-MSCs) in the treatment of dogs with acute paraplegia. Twenty-two adult dogs of different breeds with acute paraplegia resulting from a Hansen type I disc herniation in the thoracolumbar region (T3-L3) were evaluated using computed tomography. All dogs had grade IV or V lesions and underwent surgery within 7 days after symptom onset. They were randomly assigned into two groups, 11 dogs in each. The dogs in Group I underwent hemilaminectomy, and those in Group II underwent hemilaminectomy and cAd-MSC epidural transplantation. In both groups, all dogs with grade IV lesions recovered locomotion. The median locomotion recovery period was 7 days for Group II and 21 days for Group I, and this difference was statistically significant (p < 0.05). Moreover, the median length of hospitalization after the surgery was statistically different between the two groups (Group I, 4 days; Group II, 3 days; p < 0.05). There were no statistically significant between-group differences regarding the number of animals with grade IV or V lesions that recovered locomotion and nociception. In conclusion, compared with surgical decompression alone, the use of epidural cAd-MSC transplantation with surgical decompression may contribute to faster locomotor recovery in dogs with acute paraplegia and reduce the length of post-surgery hospitalization.

ResumoO presente trabalho teve por objetivo avaliar a percepção sobre guarda responsável, zoonoses, controle populacional de cães e gatos e a situação de cães de rua, de uma amostra de pessoas pertencentes à Pontifícia Universidade Católica do Paraná. Para isso foram enviados questionários online com 22 perguntas. Participaram dessa pesquisa 239 pessoas, a maioria do sexo feminino, com faixa etária entre 25 e 35 anos, com ensino superior completo, residentes principalmente em Curitiba/PR. Possuíam cão ou gato como animal de estimação, 57% dos respondentes, e em relação à quantidade de animais por respondente, o número médio de cães foi de 2,62 ± 1,35 e gatos de 1,56 ± 1,07. Tanto proprietários de cães como gatos, afirmaram praticar com regularidade a vacinação, administração de vermífugos e atendimento veterinário de seus animais. O acesso dos cães à rua foi realizado com coleira e guia por 50,53% dos respondentes. Em relação à zoonose, 62% afirmaram saber o que é e conseguiram citar um exemplo. Sobre a presença de animal solto no seu bairro, 78% dos respondentes afirmaram que sim, 49% observaram que há cães de rua que são mantidos por alguém e 71% afirmaram que o responsável pelo controle desses animais deve ser o governo e a sociedade. Diante das respostas obtidas, foi possível identificar que essa amostra populacional reconheceu seis tipos de zoonoses, percebeu a importância da guarda responsável de cães e gatos e afirmou que não haja um único responsável pelos cães de rua.Palavras-chave: animais de rua, controle populacional, educação, saúde pública. AbstractThis study aimed to evaluate the perception of responsible custody, zoonosis, population control of cats and dogs and the situation of stray dogs in a sample of people belonging to the Pontifical Catholic University of Paraná. For this online questionnaires with 22 questions was sent. 239 people participated in this survey, the majority were female, aged between 25-35 years with complete living mainly in Curitiba / PR higher education. They had a dog or cat as a pet, 57% of respondents, and relative to the amount of animals responding by, the average number of dogs was 2.62 ± 1.35 and 1.56 ± 1.07 for cats. Both dog owners like cats, practicing regularly said vaccination administration of wormers and vet care for their animals. The access of the street dogs was held with collar and leash by 50.53% of respondents. Regarding zoonosis, 62% claimed to know what it is and managed to cite an example. About the presence of loose animals in your neighborhood, 78% of respondents said yes, 49% noted that there stray dogs that are kept by someone, and 71% stated that the responsibility for controlling these animals should be the government and society. Given the responses, we found that this sample population recognized six types of zoonosis, realized the importance of responsible dog guard and cats and stated that there is no single responsible for stray dogs.