Mycotoxins and their consequences in aquaculture: A review

Anater, Amanda; Manyes, Lara; Meca, Giuseppe; Ferrer, Emilia; Luciano, Fernando Bittencourt; Pimpão, Cláudia Turra; Font, Guillermina

doi:10.1016/j.aquaculture.2015.08.022

Cited by 180 publications

(127 citation statements)

References 46 publications

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“…The high rate of mortality (19% was observed only in the T3 group treated with the highest dose of T-2 toxin) confirms that T-2 toxin has the highest toxicity among trichothecene mycotoxins even in fishes (Anater et al, 2016).…”

Section: Discussionmentioning

confidence: 66%

Short-term effects of T-2 toxin or deoxynivalenol on lipid peroxidation and the glutathione system in common carp

Pelyhe

Kövesi

Zándoki

et al. 2016

Acta Veterinaria Hungarica

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The purpose of this study was to investigate the short-term effects of a single oral dose of T-2 and HT-2 toxin at 0.15, 0.33 and 1.82 mg kg -1 body weight, or deoxynivalenol (DON) and 15-acetyl-DON at 0.13, 0.31 and 1.75 mg kg -1 body weight in common carp. Conjugated dienes and trienes (the early markers of lipid peroxidation) were elevated in all DON-treated groups at the 16th hour, while thiobarbituric acid reactive substances (TBARS; termination marker) were increased at the highest dose of DON at the 16th and 24th hours. T-2 toxin did not cause changes in these parameters. Glutathione content and glutathione peroxidase activity showed higher levels at the 16th hour as the effect of both mycotoxins. The expression of glutathione peroxidase (GPx4) genes (gpx4a and gpx4b) revealed a dual response. Downregulation was observed at the 8th hour, followed by an induction at the 16th hour, at the lowest dose of both mycotoxins. Higher doses revealed long-drawn emergence and an elevation was observed only at the 24th hour. However, at the lowest and highest doses of DON or T-2 toxin the changes in gene expression were delayed, which may be related to the low oxidative stress response, as suggested by the expression profiles of the nrf2, keap1, gpx4a and gpx4b genes.

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Section: Discussionmentioning

confidence: 66%

Short-term effects of T-2 toxin or deoxynivalenol on lipid peroxidation and the glutathione system in common carp

Pelyhe

Kövesi

Zándoki

et al. 2016

Acta Veterinaria Hungarica

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“…Substancje te mogą znacznie obniżać opłacalność hodowli ryb (np. poprzez redukcję przyrostów masy ciała) oraz stanowić ryzyko dla zdrowia ludzi (1,15). Na stan zdrowia zwierząt wpływa wiele czynników, takich jak: aktualny dobrostan, ekspozycja na patogeny, status immunologiczny oraz predyspozycje osobnicze.…”

Section: Artykuł Przeglądowy Reviewunclassified

“…Wraz z krwią trafiają do wątroby, gdzie ulegają dalszemu metabolizmowi, a ich sekrecja następuje głównie poprzez wydalanie z moczem. Jak dotąd tylko u niektórych gatunków ryb wykazano właściwości hepatotoksyczne i karcinogenne aflatoksyn (1,3). U pstrąga tęczowego zaobserwowano działanie hepatotoksyczne aflatoksyny B1 (AFB1), którą podawano w paszy w dawce 80 µg/kg paszy.…”

Section: Abstract: Mycotoxins Fish Health Feedsunclassified

“…Obniżone przyrosty wagowe obserwowano u suma kanałowego, któremu podawano paszę zawierającą fumonizyny na poziomie 5-8 mg/kg paszy (1,23). Ponadto obniżone przyrosty wagowe zaobserwowano u łososia atlantyckiego i pstrąga tęczowego po podaniu paszy skażonej deoksyniwalenolem (0,3-3,7 mg/kg paszy) (1). Nie zaobserwowano natomiast różnic wagowych między grupą kontrolną a grupą badaną wśród karpi, którym podawano paszę z dodatkiem deoksyniwalenolu na poziomie 352-953 µg/kg paszy (33).…”

Section: Abstract: Mycotoxins Fish Health Feedsunclassified

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Influence of mycotoxins on fish health

Walczak¹,

Jedziniak²,

Reichert³

2018

Medycyna Weterynaryjna

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Mycotoxins are a wide group of compounds that often occur in food and feeds. These toxins negatively affect living organisms and may pose a risk for consumers’ health. Fish seem to be a particularly vulnerable group because negative effects can be observed at low levels of contamination, much lower than those considered harmful for other farmed animals. Mycotoxins may disturb cellular homeostasis by their influence on cells’ metabolism, causing DNA damage and organ lesions. Moreover, they are capable of immunomodulation, which may increase the occurrence of fish diseases caused by bacteria and other pathogens. Furthermore, these substances often have a negative impact on the growth rate of fish, which may cause economic losses to farmers. Although mycotoxins are commonly found in feeds, their ability to bioaccumulate in fish seems to be marginal. Therefore, according to the available data, fish may not be considered as the main source of mycotoxins for humans. Since there are no legal limits on the amount of mycotoxins present in fish feeds, it is necessary to constantly monitor the levels of mycotoxins in fish feeds and to investigate the influence of these substances on fish health..

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