A silica-based cation-exchange column was used to determine ence of arsenocholine in DORM 1 was questioned and suggested to be the tetramethylarsonium cation.6 the arsenic compounds in the National Research Council of Canada (NRCC ) CRMs DORM 1 and DORM 2 (Dogfish This paper reports the arsenic compounds identified in the dogfish reference materials DORM 1 and DORM 2 [separation Muscle). With a 20 mM aqueous pyridine mobile phase at pH 3.0, the concentration of arsenobetaine was only on anion-or cation-exchange columns, arsenic-specific detection by inductively coupled argon plasma mass spectrometry 10.7 mg kg−1 As in the extract of DORM 1. When the same extract was chromatographed on an anion-exchange column, (ICP-MS)] and a method to prevent the reduction of the signal for arsenobetaine by the matrix components Na and K. 15.9±0.3 mg kg−1 As (arsenobetaine) were found. The calibration for arsenobetaine was linear from 0.5 mg dm−1 As to 10 mg dm−3 As. When the extracts were diluted with water the cation-exchange results approached the anion-exchange EXPERIMENTAL results. The multi-element capabilities of ICP-MS allowed the Reagents and solutions simultaneous monitoring of arsenic and alkali metals. Sodium and potassium were found to co-elute with arsenobetaine.DORM 1 and DORM 2 (Dogfish Muscle Tissue) were When aqueous solutions of arsenobetaine with purchased from the NRCC,
First void urine samples were collected from 24 residents in an area of past intense mining and smelting activity of arsenical ores. Seven samples were also taken from a control village. The arsenic species in the urine were separated and quantified with an HPLC-ICP-MS system equipped with a hydraulic high-pressure nebulizer. The detection limit for arsenic in urine using this system is 0.05 microgram dm-3. Creatinine was also determined for all samples to remove the influence of urine density and all results were expressed in microgram As g-1 creatinine. The results showed elevated levels of both organic and inorganic arsenic compounds in the 'exposed' population's urine when compared with those of the control group. The total As concentrations (less arsenobetaine) in the 'exposed' population were in the range 2.7-58.9 micrograms g-1 creatinine (mean 13.4, median 9.2 micrograms g-1) compared with the control group data range 2.5-5.3 micrograms g-1 (mean 4.2, median 4.7 micrograms g-1).
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