This study aimed on evaluating the possible effects of tetracycline administered to rats on the tenth day of pregnancy, on kidney and liver development of their offspring. The liver showed vacuolization, necrosis, inflammation and sinusoidal dilatations, more evident in the newborn. Mitosis, early increase of Kupffer cells population and hipertrophy of hepatocytes with greater synthesis of glycogen were present on the tenth and twentieth days of life. The kidney showed slight tubular vacuolizations and necrosis, more proeminent in the newborn, as well as signs of tubular regeneration on the tenth and twentieth days. These results suggested that the organs studied went through several transitory morphological changes during development but presented signs of regeneration along the first days of life.
O objetivo deste estudo foi avaliar os possíveis efeitos da tetraciclina administrada a ratas, no décimo dia de gestação, no desenvolvimento hepático e renal de seus filhotes. O fígado mostrou vacuolização, necrose, inflamação e dilatação sinusoidal mais evidente em recém-nascidos. Mitoses, aumento precoce da população de células de Kupffer e hipertrofia de hepatócitos com maior síntese de glicogênio estavam presentes no décimo e vigésimo dias de vida. O rim mostrou vacuolização tubular e necrose discretas, mais evidentes nos recém-nascidos, assim como sinais de regeneração tubular no décimo e vigésimo dias. Esses resultados sugeriram que os órgãos estudados sofreram alterações morfológicas transitórias durante o desenvolvimento, mas apresentaram sinais de regeneração ao longo dos primeiros dias de vida
This research proposes to study sodium alendronate effect on bone repair of ovarectomized rats. Thirty-six adult rats were ovariectomized and distributed in four groups, with nine rats in each group. A surgical defect was performed in one tibia of each animal. The control group received only water "ad libitum" and the three experimental groups received sodium alendronate diluted in the drinking water in the doses of 0.25 mg/kg; 0.5 mg/kg e 0.75 mg/kg, respectively. Three animals of each group were sacrificed after three, seven and 14 days. The histhologic analysis of the tibia material showed a more marked bone deposition in the groups treated with higher doses of sodium alendronate. The most mature bone repair process was observed in the 14-days/0.5 mg/kg group, with bone spindles and remodeling in a higher degree of development, showing a dose-dependency regarding sodium alendronate.
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