Changes in hippocampal subfield volumes (HSV) along the Alzheimer's disease (AD) continuum have been scarcely investigated to date in elderly subjects classified based on the presence of β-amyloid aggregation and signs of neurodegeneration. We classified patients (either sex) with mild dementia compatible with AD (n = 35) or amnestic mild cognitive impairment (n = 39), and cognitively unimpaired subjects (either sex; n = 26) using [ 11 C]PIB-PET to assess β-amyloid aggregation (A+) and [ 18 F]FDG-PET to account for neurodegeneration ((N)+). Magnetic resonance imaging-based automated methods were used for HSV and white matter hyperintensity (WMH) measurements. Significant HSV reductions were found in A+(N)+ subjects in the presubiculum/subiculum complex and molecular layer, related to worse memory performance. In both the A+(N)+ and A+(N)− categories, subicular volumes were inversely correlated with the degree of Aβ deposition. The A−(N)+ subgroup showed reduced HSV relative to the A−(N)− subgroup also in the subiculum/presubiculum. Combining all (N)− subjects, HSV were lower in subjects presenting significant cognitive decline irrespective of A+/A− classification (controlling for WMH load); these between-group differences were detected again in the presubiculum, but also involved the CA4 and granular layer. These findings demonstrate that differential HSV reductions are detectable both in (N)+ and (N)− categories along the AD continuum, and are directly related to the severity of cognitive deficits. HSV reductions are larger both in A+(N)+ and A+(N)− subjects in direct proportion to the degree of Aβ deposition. The meaningful HSV reductions detected in the A−(N)+ subgroup highlights the strength of biomarker-based classifications outside of the classical AD continuum.

AGRADECIMENTOSTenho poucas certezas na vida, mas uma delas é a de que muitas pessoas contribuíram para a realização deste trabalho. Serei eternamente grata a todos vocês, obrigada! À professora Sílvia Martorano Raimundo, pelas inúmeras aulas e discussões conceituais e, principalmente, pela dedicação, carinho e verdadeira amizade que sempre estiveram presentes em todos os momentos.Ao professor Marcelo Nascimento Burattini, pela orientação, pelas sugestões conceituais e apoio no processo de execução do trabalho.Ao professor Eduardo Massad, por ter me proposto o tema para este trabalho, por propiciar condições técnicas e financeiras para que ele fosse realizado e, principalmente, por ter acreditado que eu conseguiria. espalhamento de rumores levando em conta a simetria no número de contatos diretos entre "suscetíveis" e "infectados" pelo rumor e estudamos as implicações de uma campanha publicitária educativa na dinâmica do modelo.Posteriormente, propomos uma simplificação do modelo e desconsideramos o contato entre os indivíduos "suscetíveis" e "infectados" mais resistentes às novidades. Discutimos suas implicações no espalhamento do rumor e a conexão com os parâmetros que descrevem o comportamento social. ABSTRACT Mathematical Model to study the spread of information from educative campaigns and rumorsWe have developed a deterministic mathematical model based on the mass-action principle, in analogy to the works that study the dynamics of infectious diseases in Epidemiology. We analyzed the dynamic of rumors spreading, taking into account the symmetry of contacts among "susceptible"and "infectious" individuals and studied the implications of an educative broadcasting advertising in the model.We also simulated the model eliminating the contact among opinioned "susceptible" and "infective" to simplify the model.

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Capítulo 1: Características associadas ao nível de evidenciação das aplicações financeiras em equivalentes de caixa nas companhias de capital aberto brasileiras ..

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Advances in transmission technology have allowed computer networks to exchange information on a large scale at speeds compatible with the needs of the information society and data communication. In this way, issues related to infrastructure became more visible and of interest to managers from different disciplines.Knowing the behavior of the network or its segments is important to know which protocols consume more resources. An important aspect of any network monitoring task is precisely related to choosing the best method to perform it. Computer networks can be used to transmit information such as images, audio, video, and various types of files.This transmission can be used for a variety of purposes, including the transmission of medical images using certain technologies such as DICOM and PACS. There are protocols that allow the integration between different medical image acquisition systems. DICOM is a communication system for digital images in medicine, represented by a set of rules created by the American Radiological Society in 1983 to facilitate the storage and communication of images. PACS is a type of technology that facilitates the communication and archiving of image files.In this context, the proposal was born in partnership with NETI -HCFMUSP, which aims to analyze the data flow of the computer network using open-source tools.The objective of this work is to analyze and interpret the data composed in these communication systems, where the flow of information carried by the hospital's computer network will be treated and visualized with the use of mathematical and computational tools.

The article presents a scientific research initiation project from Centro Universitário 5SENAC entitled Case study on the IT professional: a look at the work stress of students working in the health area and results (our emphasis). It should be noted that occupational stress, as a causal link for absence from work, ranks second in reasons for work-related illness in Brazil (MPS -ministério previdência social, 2022). Concomitant to this scenario, there is a significant increase in professionals in the IT sector, a context of alert since mental health is already notably a business challenge. Therefore, the study seeks to present the factors that cause occupational stress, which intersect the specific work environment of information technology (IT) professionals, as well as to present its consequences and possible mitigating agents. The article delimits the study of the information technology area given the breadth of the topic. For this, a literature review was carried out on the main themes in the first stage and second, an exploratory research with authors in the semi-structured phase referring to the perception of IT regarding the reasons that generate occupational stress. The data were treated statistically and related to the theoretical framework that discusses the subject. It can be evidenced with an investigation that the IT sector is full of stressors given the deadlines for carrying out projects usually short, long working hours, in addition to the lack of organization of the scope of work, as well as the agent necessary to ensure the worker's mental health.