physiological refinement over their method in that air can be trapped in localized lung areas while adjacent lung tissues will remain relatively collapsed and resilient as is known to occur clinically. In addition. these animals remain in good health for long periods of time and are available for various types of espcrinients.Par tially obstructive endobr onchial lesions have been produced in dogs bj. transbronchial injection of a plastic material, These lesions were composed primarily of large accumulations of Lracuol a t ed macro-S u n i~m r .~.phages, The size of these masses was apparently dependent upon their age, The implication of this type of lesion in possible production of evperirnental emphysema has been discussed.
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