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CSF CoGO BI2 BINDING CAPACITY 60 7 animal. In our experiments doses several times the lethal dose elicited no responses which suggested release of significant amounts of histamine, Summary. 1) In anesthetized rabbits, lethal doses of compound 48/80 produced marked depression of respiration with ensuing blood pressure changes that could be altered by administering artificial respiration. Blood pressure and electrocardiographic records in animals artificially respired soon after receiving doses several times the lethal dose revealed no evidence of adverse effects on the vascular system or on cardiac rate and rhythm. 2 ) Under similar conditions, however, a lethal dose of histamine produced a prompt and profound fall in blood pressure, marked changes in cardiac rate and rhythm and death despite artificial respiration. The effect appears to be primarily on the cardiovascular system. Respiratory effects are prob-aldy secontlary to this main action. 3 ) The lethal action of 48/80 in rabbits is apparently not mediated by release of endogenous histamine since large doses do not elicit histaminelike responses.

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