Neurofibromatosis type-1 (NF1) is a common genetic disorder associated with a variety of medical complications, cognitive impairments, and behavioral problems. One hundred and sixteen patients with NF1 (62 males, 54 females; mean age 12.4 years) and 80 typically developing children of the same ages (46 males, 34 females; mean age 11.5 years) were studied in terms of complications and learning impairment (one or more grade repetitions or school exclusion). Seventy of 116 patients had significant learning impairment. Classical complications were present in 53 patients including the three.
The fall in the prevalence of left-handedness with age has been attributed to the effect of forced dextrality on handwriting. The purpose of this study was to assess handwriting preference in a cohort of children and adult participants in order to study the correlation between age and incidence of sinistrality. A strong preference for right handwriting across all ages with a decrease in sinistrality with age (18% in those under 20 versus 3% in those over 60) was observed. This phenomenon was not continuous, and a dramatic drop at age 30-40 years might be attributed to changes in educational management during the 1960s, especially after the events of May 1968 in France.
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