Early Grade Repetition and Inattention Associated With Neurofibromatosis Type 1

Coudé, F. X.; Mignot, Claire; Lyonnet, Stanislas; Münnich, Arnold

doi:10.1177/1087054707299398

Cited by 22 publications

(20 citation statements)

References 12 publications

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“…Children with NF1 may have a fourfold increased risk of using special education services and a sixfold increased risk of receiving remedial teaching for learning, behaviour, speech, or motor problems; 51 only 10% of children with NF1 did not show any school‐functioning problems 51 . In another study, 53% of 310 children with NF1 had to repeat at least one grade in school, compared with 25% of 242 children without NF1 52 . Fifty‐six adults with NF1 reported difficulties at school; 60% reported difficulties with school work in junior school, 32% reported being unhappy at school, and 13% stated that their unhappiness at school was directly related to their NF1 24 .…”

Section: Application Of the Icf‐cy To The Profile Of Children With Nf1mentioning

confidence: 98%

Application of the International Classification of Functioning, Disability and Health in children with neurofibromatosis type 1: a review

Gilboa

Rosenblum

Fattal‐Valevski

et al. 2010

Develop Med Child Neuro

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Health adapted for children and young people (ICF-CY) is a framework for describing and classifying health and health-related states. The aim of the present study was to review literature on neurofibromatosis type 1 (NF1) using ICF-CY guidelines and to highlight findings about the quality of life of children with NF1.METHOD Electronic databases were searched to identify studies involving children with NF1.Eligible studies were classified according to ICF-CY categories.RESULTS Children with NF1 have a variety of cognitive and other deficits. However, very little information is available on the impact of these deficits on their daily life.

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Section: Application Of the Icf‐cy To The Profile Of Children With Nf1mentioning

confidence: 98%

Application of the International Classification of Functioning, Disability and Health in children with neurofibromatosis type 1: a review

Gilboa

Rosenblum

Fattal‐Valevski

et al. 2010

Develop Med Child Neuro

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“…The cognitivebehavioral phenotype of NF1 is characterized by specific learning difficulties, neuropsychological deficits, attention deficit hyperactivity disorder (ADHD), and social, emotional and behavioral problems . ADHD is most commonly reported with prevalence estimates ranging from 30-67 % (Coude et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Autism Spectrum Disorder Profile in Neurofibromatosis Type I

Garg

Plasschaert

Descheemaeker

et al. 2014

J Autism Dev Disord

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Neurofibromatosis Type 1 (NF1) is a common autosomal dominant single-gene disorder, in which the co-occurrence of autism spectrum disorder (ASD) has attracted considerable research interest recently with prevalence estimates of 21-40%. However, detailed characterization of the ASD behavioral phenotype in NF1 is still lacking. This study characterized the phenotypic profile of ASD symptomatology presenting in 4-16 year old children with NF1 (n = 36) using evidence from parent-rated Social Responsiveness Scale and researcher autism diagnostic observation Scale-2. Compared to IQ-matched reference groups of children with autism and ASD, the NF1 profile shows overall similarity but improved eye contact, less repetitive behaviors and better language skills.

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“…The ADHD-like behaviour in the NF1 population may be a major contributor to academic underachievement in this population [16]. Children with NF1 have difficulties with social interactions, and present a high frequency of internalising features such as anxiety and depression [4].…”

Section: Introductionmentioning

confidence: 99%

The effect of methylphenidate on neurofibromatosis type 1: a randomised, double-blind, placebo-controlled, crossover trial

Lion‐François¹,

Gueyffier

Mercier

et al. 2014

Orphanet J Rare Dis

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BackgroundNeurofibromatosis type 1 (NF1) is an autosomal dominant disorder with an estimated prevalence of about 1/3000, independent of ethnicity, race, or gender. Attention Deficit Hyperactivity like Disorder (ADHD)-like characteristics are often reported in patients with NF1. We hypothesised that learning disabilities in NF1 children were related to ADHD symptoms. Treatment with methylphenidate (MPD) has improved learning disabilities in ADHD by acting on neurotransmitters. Our objective was to evaluate its efficacy on ADHD-like symptoms in neurofibromatosis type 1 children (7–12 years).MethodsThis was a randomised, double blind, placebo controlled, and crossover trial comparing 0.5 to 0.8 mg/kg/d of MPD as it is indicated for ADHD to placebo in NF1 children with ADHD-like symptoms. Children aged 7 to 12 years were eligible when their IQ was between 80 and 120. The total follow-up was 9 weeks including 4 weeks for each period and 1 week wash out. Fifty subjects (25 for each period) were required for testing the primary study hypothesis. The main outcome was an improvement in scores on the simplified Conners’ Parent Rating Scale.ResultsThirty-nine patients were included between April 2004 and December 2010. Twenty participants received MPD and 19 placebo during the first period. They all completed the trial. MPD decreased the simplified Conners by 3.9 points (±1.1, p = 0. 0003).ConclusionsThis is the first randomised controlled trial showing the short-term benefit of MPD on simplified Conners scores in NF1 children.Trial registrationClinicalTrials.gov NCT00169611.

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Early Grade Repetition and Inattention Associated With Neurofibromatosis Type 1

Abstract: Grade repetition is a frequent complication in NF1 and correlates with inattention in individuals with this disease.

Cited by 22 publications

References 12 publications

Application of the International Classification of Functioning, Disability and Health in children with neurofibromatosis type 1: a review

Application of the International Classification of Functioning, Disability and Health in children with neurofibromatosis type 1: a review

Autism Spectrum Disorder Profile in Neurofibromatosis Type I

The effect of methylphenidate on neurofibromatosis type 1: a randomised, double-blind, placebo-controlled, crossover trial

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