Natural products used in the traditional systems of medicine exhibit a various and promising resource in human health. However, these products are often characterized for their chemical composition as well as mechanisms of action. Considering the bacterial infections play an important role in human diseases, it is necessary to develop new antibacterial herbal products. The aim of this study was to isolation and structural identification of hesperidin from Citrus sinensis L. and to formulate hesperidin loaded to water-in-oil (w/o) microemulsion as an inovative formulation for bactericidal treatment. This present study indicates that hesperidin microemulsion has antibacterial activity against various types of bacteria according to MIC method. All strains were showed logaritmic reduction. These findings indicated that the microemulsion as a drug carrier, especially hesperidin formulation, may be used as an effective antibacterial therapy.
5-Fluorouracil is one of the first line drugs for the systemic therapy of solid tumors like breast, colorectal, oesophageal, stomach, pancreatic, head and neck. It could be shown that sugars can improve the absorption across cell membranes and can help to bypass some pharmacokinetic problems. Carbohydrates as most common organic molecules are an important issue of plant and animal metabolisms. They are non toxic and have important duties in the body like participating in DNA and RNA synthesis and being responsible for energy production. In addition, they have many hydroxyl, aldehyde and ketone groups that attract attention for synthesis as a potential drug derivative. 1,2,3,-Triazole compounds have also important role in heterocyclic chemistry because of their pharmaceutical properties and their high reactivity, which could be used as a building block for complex chemical compounds. In this study, following the "Click Reaction" of 5-FU and tetra--acetylglycose the 5-fluorouracil derivative 1-[{1'-(2″,3″,4″,6″-tetra--acetyl--d-glycopyronosyl)-1'-1',2',3'-triazole-4'-yl} methyl]5-fluorouracil was synthesized. Following, a micellar formulation of 5-Fluorouracil derivative was prepared and characterized in terms of particle size, polydispersity index, zeta potential, refractive index and pH. Furthermore, the cytotoxicity and mutagenicity of the 5-fluorouracil derivative was investigated using an cell culture model and the AMES test. According to the results of this study, the novel 5-fluorouracil derivative could be a drug candidate for the therapy of cancer and needs further investigations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.