An
increasing utilization of flexible healthcare electronics and
biomedicine-related therapeutic materials urges the development of
multifunctional wearable/flexible smart fabrics for personal therapy
and health management. However, it is currently a challenge to fabricate
multifunctional and on-body healthcare electronic devices with reliable
mechanical flexibility, excellent breathability, and self-controllable
joule heating effects. Here, we fabricate a multifunctional MXene-based
smart fabric by depositing 2D Ti3C2T
x
nanosheets onto cellulose fiber nonwoven fabric via special MXene–cellulose fiber interactions. Such
multifunctional fabrics exhibit sensitive and reversible humidity
response upon H2O-induced swelling/contraction of channels
between the MXene interlayers, enabling wearable respiration monitoring
application. Besides, it can also serve as a low-voltage thermotherapy
platform due to its fast and stable electro-thermal response. Interestingly,
water molecular extraction induces electrical response upon heating, i.e., functioning as a temperature alarm, which allows for
real-time temperature monitoring for thermotherapy platform without
low-temperature burn risk. Furthermore, metal-like conductivity of
MXene renders the fabric an excellent Joule heating effect, which
can moderately kill bacteria surrounding the wound in bacteria-infected
wound healing therapy. This work introduces a multifunctional smart
flexible fabric suitable for next-generation wearable electronic devices
for mobile healthcare and personal medical therapy.
An all-weather steam generation system is achieved based on the alternative photo-thermal and electro-thermal conversion of crosslinked MXene aerogels.
Acute kidney injury (AKI), as a common oxidative stress-related renal disease, causes high mortality in clinics annually, and many other clinical diseases, including the pandemic COVID-19, have a high potential to cause AKI, yet only rehydration, renal dialysis, and other supportive therapies are available for AKI in the clinics. Nanotechnology-mediated antioxidant therapy represents a promising therapeutic strategy for AKI treatment. However, current enzyme-mimicking nanoantioxidants show poor biocompatibility and biodegradability, as well as non-specific ROS level regulation, further potentially causing deleterious adverse effects. Herein, the authors report a novel non-enzymatic antioxidant strategy based on ultrathin Ti 3 C 2 -PVP nanosheets (TPNS) with excellent biocompatibility and great chemical reactivity toward multiple ROS for AKI treatment. These TPNS nanosheets exhibit enzyme/ROS-triggered biodegradability and broad-spectrum ROS scavenging ability through the readily occurring redox reaction between Ti 3 C 2 and various ROS, as verified by theoretical calculations. Furthermore, both in vivo and in vitro experiments demonstrate that TPNS can serve as efficient antioxidant platforms to scavenge the overexpressed ROS and subsequently suppress oxidative stress-induced inflammatory response through inhibition of NF-B signal pathway for AKI treatment. This study highlights a new type of therapeutic agent, that is, the redox-mediated non-enzymatic antioxidant MXene nanoplatforms in treatment of AKI and other ROS-associated diseases.
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