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Security assessment of Thermal Power Plants (TPPs) is one of the important means to guarantee the safety of production in thermal power production enterprises. Essentially, the evaluation of power plant systems relies to a large extent on the knowledge and length of experience of the experts. Therefore in this domain Case-Based Reasoning (CBR) is introduced for the security assessment of TPPs since this methodology models expertise through experience management. Taking the management system of TPPs as breakthrough point, this paper presents a case-based approach for the security assessment decision support of TPPs (SATPP). First, this paper reviews commonly used approaches for TPPs security assessment and the current general evaluation process of TPPs security assessment. Then a framework for the Management System Security Assessment of Thermal Power Plants (MSSATPP) is constructed and an Intelligent Decision Support System for MSSATPP (IDSS-MSSATPP is functionally designed. MSSATPP involves several key technologies and methods suchas knowledge representation and case matching. Keywords-thermal power plants; intelligent decision support;safety assessment; case-based reasoning; service system ___________________________________ 978-1-61284-109-0/11/$26.00 ©2011 IEEE As shown in Fig.3, for the sake of providing better support for experts, model based and method based components are also designed in IDSS-MSSATPP. Moreover, the security domain knowledge base of TPPs production is also contained. With these functions, the reasoning ability of IDSS-MSSATPP will get significantly increased. Not only can it be used to for knowledge acquisition, further, it is able to be used for case reuse and the maintenance of the case base.