Background: Methoprene-tolerant (Met) and Germ-cell expressed belonging to the bHLH-PAS family have been identified as juvenile hormone (JH) receptors in Drosophila. Results: Physical interaction with Hsp83 facilitates nuclear import of Met and JH action. Conclusion: Hsp83 modulates JH signaling through mediating the nuclear localization of Met. Significance: Our study helps in understanding the complicated molecular mechanisms of JH signaling.
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