Mosquito Microbiota and Implications for Disease Control

Gao, Han; Cui, Chunlai; Wang, Lili; Jacobs-­Lorena, Marcelo; Wang, Sibao

doi:10.1016/j.pt.2019.12.001

Cited by 103 publications

(104 citation statements)

References 106 publications

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“…Evidence from other insect systems shows a role for commensal microbes influencing behavior [21,22]. In mosquiotes, pathogen infection can also reduce feeding rates and host seeking behavior, possibly by altering expression of odorant binding proteins or immunity-related genes [23][24][25][26]; however, less know how gut-associated microbes alter these phenotypes. Therefore, a greater appreciation of factors that influence colonization of the mosquito gut and how microbes effect the host is critical for deploying microbial-based approaches to control mosquitoborne disease [23,24].…”

Section: Introductionmentioning

confidence: 99%

Microbial interactions in the mosquito gut determine Serratia colonization and blood-feeding propensity

et al. 2020

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How microbe–microbe interactions dictate microbial complexity in the mosquito gut is unclear. Previously we found that, Serratia, a gut symbiont that alters vector competence and is being considered for vector control, poorly colonized Aedes aegypti yet was abundant in Culex quinquefasciatus reared under identical conditions. To investigate the incompatibility between Serratia and Ae. aegypti, we characterized two distinct strains of Serratia marcescens from Cx. quinquefasciatus and examined their ability to infect Ae. aegypti. Both Serratia strains poorly infected Ae. aegypti, but when microbiome homeostasis was disrupted, the prevalence and titers of Serratia were similar to the infection in its native host. Examination of multiple genetically diverse Ae. aegypti lines found microbial interference to S. marcescens was commonplace, however, one line of Ae. aegypti was susceptible to infection. Microbiome analysis of resistant and susceptible lines indicated an inverse correlation between Enterobacteriaceae bacteria and Serratia, and experimental co-infections in a gnotobiotic system recapitulated the interference phenotype. Furthermore, we observed an effect on host behavior; Serratia exposure to Ae. aegypti disrupted their feeding behavior, and this phenotype was also reliant on interactions with their native microbiota. Our work highlights the complexity of host–microbe interactions and provides evidence that microbial interactions influence mosquito behavior.

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Section: Introductionmentioning

confidence: 99%

Microbial interactions in the mosquito gut determine Serratia colonization and blood-feeding propensity

et al. 2020

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“…After being sucked up in blood, pathogens infect the gut epithelial cells, enter the hemolymph, invade the salivary glands, and the mosquito can then transmit the pathogen while biting a healthy host. [3]. The most important mosquito-borne diseases are transmitted by three mosquito genera (Anopheles, Aedes, and Culex).…”

Section: Introductionmentioning

confidence: 99%

“…In addition to nematodes (Dirofilaria spp. ), Aedes mosquitoes transmit several arboviruses, including dengue, chikungunya, West Nile, Zika, and yellow fever viruses [3]. Mosquito-borne diseases with significant public health concern and mycobiota detected along the mosquito life cycle.…”

Section: Introductionmentioning

confidence: 99%

“…In the past decades, mosquito vectors have expanded their global distribution [4,5], favored by global warming and human activities such as international trade or urban expansion [6][7][8]. This leads to the emergence of mosquito-borne diseases in new geographic areas and causes major public health concerns [3]. In the absence of effective preventive treatments against most pathogens transmitted, vector control remains one of the most suitable strategies against mosquito-borne diseases.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to nematodes ( Dirofilaria spp. ), Aedes mosquitoes transmit several arboviruses, including dengue, chikungunya, West Nile, Zika, and yellow fever viruses [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mosquito Mycobiota: An Overview of Non-Entomopathogenic Fungal Interactions

2020

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The growing expansion of mosquito vectors leads to the emergence of vector-borne diseases in new geographic areas and causes major public health concerns. In the absence of effective preventive treatments against most pathogens transmitted, vector control remains one of the most suitable strategies to prevent mosquito-borne diseases. Insecticide overuse raises mosquito resistance and deleterious impacts on the environment and non-target species. Growing knowledge of mosquito biology has allowed the development of alternative control methods. Following the concept of holobiont, mosquito-microbiota interactions play an important role in mosquito biology. Associated microbiota is known to influence many aspects of mosquito biology such as development, survival, immunity or even vector competence. Mosquito-associated microbiota is composed of bacteria, fungi, protists, viruses and nematodes. While an increasing number of studies have focused on bacteria, other microbial partners like fungi have been largely neglected despite their huge diversity. A better knowledge of mosquito-mycobiota interactions offers new opportunities to develop innovative mosquito control strategies. Here, we review the recent advances concerning the impact of mosquito-associated fungi, and particularly nonpathogenic fungi, on life-history traits (development, survival, reproduction), vector competence and behavior of mosquitoes by focusing on Culex, Aedes and Anopheles species.

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Insect‐specific viruses used in biocontrol of mosquito‐borne diseases

Chen

Deng

Peng

2023

Interdisciplinary Medicine

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Mosquito-borne diseases, such as malaria, dengue, Zika, and West Nile, have caused substantial disease burdens to the people living in tropical and subtropical regions. Despite decades of efforts in control, the prevalence, geographic distribution, and severity of these diseases are still deteriorating and the options for vector control are limited. Insect-specific viruses (ISVs) can naturally infect and replicate in mosquitoes, and even be vertically transmitted from generation to generation, interfering with arbovirus' proliferation, and disturbing mosquito's physiology, which are harmless to vertebrates and have great potential for bio-control. Insect-specific RNA viruses (ISRVs) infection will inhibit the replication of mosquito-borne viruses, which may be due to the close phylogeny of ISRVs and the arboviruses. Mosquito baculoviruses (MBVs) and mosquito densoviruses (MDVs) belong to insect-specific DNA viruses. The former has limited pathogenicity to mosquitoes, while the latter can be horizontally and vertically transmitted in mosquitoes, resulting in habitat pollution, abnormal development or death of larvae and adults. In addition, ISVs can be used as fusion expression vectors to express insect virulence proteins in mosquitoes or directly inactivate important genes of mosquitoes. However, there are still many deficiencies in ISVs research studies. Clarification of the host limit mechanism for each ISVs and application of more targeted and efficient ISVs or toxins will be the future research directions.

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Mosquito Microbiota and Implications for Disease Control

Cited by 103 publications

References 106 publications

Microbial interactions in the mosquito gut determine Serratia colonization and blood-feeding propensity

Microbial interactions in the mosquito gut determine Serratia colonization and blood-feeding propensity

Mosquito Mycobiota: An Overview of Non-Entomopathogenic Fungal Interactions

Insect‐specific viruses used in biocontrol of mosquito‐borne diseases

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