Saturated fatty acids (FA) exert adverse health effects and are more likely to cause insulin resistance and type 2 diabetes than unsaturated FA, some of which exert protective and beneficial effects. Saturated FA, but not unsaturated FA, activate Jun N terminal kinase (JNK), which has been linked to obesity and insulin resistance in mice and men. However, it is unknown how saturated and unsaturated FA are discriminated. We now demonstrate that saturated FA activate JNK and induce insulin resistance by altering the membrane distribution of c-Src, causing it to partition into intracellular membrane subdomains where it may become activated. Conversely, unsaturated FA with known beneficial effects on glucose metabolism prevent c-Src membrane partitioning and activation, which are dependent on its myristoylation, and block JNK activation. Consumption of a diabetogenic high fat diet causes the partitioning and activation of c-Src within detergent insoluble membrane subdomains of adipocytes.

A threadlike structure in blood vessels that is considered part of the Bohghan duct system was first reported about 40 years ago. This structure has remained elusive since then due to the inability of other researchers to duplicate the original identification. In this study we identified the characteristic features of this threadlike structure in rats by the use of fluorescent microscope imaging of nuclei stained by acridine orange perfusion. The nuclei of the tissue that comprises the structure are rod-shaped, 10 -20 m long, and aligned in a broken-line striped fashion. The novel technique reported here can differentiate the intravascular threadlike structure from the fibrin strings that normally form during perfusion and can confound the observation procedure. The physiological function of the threadlike structure remains to be elucidated; however, further study may provide a new understanding of mammalian biology in general, and of acupuncture and Oriental medicine in particular. Anat Rec (Part B: New Anat) 278B:27-30, 2004.

We conducted a systematic study on nanopatterning by multiple-ion-beam sputtering, focusing on the superposition of the simple patterns formed by individual ion beams. When Au(001) is simultaneously sputtered by two ion beams at grazing incidence, both nanodot and nanohole patterns are obtained. If a rippled surface is subsequently sputtered at normal incidence, a nanobead pattern is obtained. All of the obtained patterns consist of the nanopatterns formed by individual ion beams; however, the superposition of nanopatterns is not realized in its ideal form. We also discuss the microscopic mechanism of pattern formation by multiple-ion-beam sputtering, and consider the questions and possibilities remaining to be explored.

We present a systematic analysis of dynamic scaling in the time evolution of the phase order parameter for coupled oscillators with nonidentical natural frequencies in terms of the Kuramoto model. This provides a comprehensive view of phase synchronization. In particular, we extend finite-size scaling (FSS) in the steady state to dynamics, determine critical exponents, and find the critical coupling strength. The dynamic scaling approach enables us to measure not only the FSS exponent associated with the correlation volume in finite systems but also thermodynamic critical exponents. Based on the extended FSS theory, we also discuss how the sampling of natural frequencies and thermal noise affect dynamic scaling, which is numerically confirmed.

No abstract