Hypermethylation of DNA in promoter CpG islands is related to transcriptional silencing of tumor suppressor genes. Histone H3-K9 methylation in different regions of the promoters studied correlates with DNA methylation status of each gene in gastric cancer cells. However, histone H3-K9 acetylation and H3-K4 methylation inversely correlate with DNA methylation status of each gene in gastric cancer cells. Alteration of DNA methylation affects histone modification.
Controlling magnetism of transition metal atoms by pairing with π electronic states of graphene is intriguing. Herein, through first -principle computation we explore the possibility of switching magnetization by forming the tetrahedral sp 3 metallic d hybrid bonds. Graphene multilayers capped by single -layer cobalt atoms can transform into the sp 3 -bonded diamond films upon the hydrogenation of the bottom surface. While the conversion is favored by hybridization between the sp 3 dangling bonds and metallic d z 2 states, such a strong hybridization can lead to the reorientation of magnetization easy axis of cobalt adatoms in plane to perpendicular. The further investigations identify that this anisotropic magnetization even can be modulated upon the change in charge carrier density, suggesting the possibility of an electric -field control of magnetization reorientation.These results provide a novel alternative that would represent tailoring magnetism by means of degree of the interlayer hybrid bonds in the layered materials.
Electronic and magnetic properties of the RB6 (R = La, Ce, Nd, Sm and Eu) crystals were investigated by using the first - principles method within the framework of the density functional theory. The ground state of lanthanum hexaboride (LaB6) is nonmagnetic crystal, while the others RB6 (R = Ce, Nd, Sm and Eu) are ferromagnetic crystal due to the partial occupations of electrons on 4f orbital for rare – earth atoms. We have done the prediction of lattice parameters, magneticmoments of magnetic ions and total magnetizations of the RB6 crystals.PACS numbers: 71.20.Eh, 75.50.-y
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