Pulsed electromagnetic field at radiofrequencies may benefit patients with benign prostate hyperplasia treated by a non-invasive method.
Objective: To present a case of acute septic arthritis due to Streptococcussanguis, a member of the viridans group streptococci. Clinical Presentation and Intervention: A 73-year-old woman presented with fever and increasing swelling and pain of the right knee several weeks after she had been treated for severe periodontal disease. Arthrocentesis yielded purulent synovial fluid. S. sanguis was isolated in synovial fluid cultures, and the patient was treated with intravenous cefotaxime for 3 weeks and repeated aspiration of the knee joint with gradual resolution of fever, joint swelling and effusion. Conclusion: Although S. sanguis is believed to be a rare cause of septic arthritis in native joints, it should be considered in the differential diagnosis of this disorder, especially in patients with recent treatment of severe dental caries and periodontal disease.
The main objective of our study is to investigate whether an enhancement of the immune system in end-stage cancer patients is achieved by exposure to coherent electromagnetic fields. For this reason, 15 end-stage cancer patients were exposed at low intensity, coherent electromagnetic fields at radiofrequencies ranging from 600 kHz-729 Hz, for 8 h/day, 6 days/week for 4 weeks. NKs number and cytotoxicity of NK T-lymphocytes versus K562 cancer cell line were estimated by flow cytometry, before and after exposure. Data showed that the exposure of the end-stage cancer patients to the coherent electromagnetic fields resulted in a significant increase of the number and the cytotoxicity of the NK T-lymphocytes against cancer cells, in all patients. Exposure to coherent EMFs at radiofrequencies increases the number and cytotoxicity of NK T-lymphocytes, which may contribute to the improvement of cancer patients' status.
Aseptic meningitis possibly associated with celecoxibTO THE EDITOR: Aseptic meningitis is a rare complication of autoimmune rheumatic diseases and a number of drugs and chemicals. 1 Several nonsteroidal antiinflammatory drugs (NSAIDs) have been associated with aseptic meningitis including ibuprofen, sulindac, tolmetin sodium, piroxicam, diclofenac, and naproxen. 2 Recently, 5 serious cases of aseptic meningitis associated with the use of rofecoxib, a recently approved selective cyclooxygenase-2 (COX-2) inhibitor, have been reported. 3 We describe a patient with an episode of aseptic meningitis during treatment with celecoxib, another selective COX-2 inhibitor. To our knowledge, there have been no published reports of aseptic meningitis in association with celecoxib use to date.Case Report. A 65-year-old woman began taking celecoxib 200 mg/d for the treatment of osteoarthritis. Five days after she began treatment, she developed fever up to 38.6˚C, headache, nausea, photophobia, confusion, and neck discomfort. On admission to the emergency department, she showed marked nuchal rigidity, positive Brudzinski and Kerning sign, mental status changes, and unremarkable cranial nerve functioning. She had no known history of drug allergies or autoimmune rheumatic disorders. Empiric ceftriaxone sodium and acyclovir therapy was administered, and celecoxib was discontinued. A chest X-ray was normal and a computed tomography scan of the head revealed no intracranial abnormalities. A complete blood cell count was within normal limits and serum biochemistry investigations showed normal results. The results of a Gram stain, tuberculosis smear, and India ink procedure were negative. There was no evidence of bacterial, acidfast bacillary, or fungal growth. Serologic tests for herpes viruses, antinuclear antibody, and rheumatoid factor were negative. The patient was diagnosed as having aseptic meningitis. Following celecoxib withdrawal, the patient's clinical condition improved. On hospital day 6, all symptoms had subsided and she was discharged from the hospital.Discussion. In our patient, there was a temporal association between the prescription of celecoxib and the development of aseptic meningitis. Furthermore, other possible causes of meningitis were carefully excluded. Use of the Naranjo probability scale indicated a possible relationship between the aseptic meningitis and celecoxib therapy in this patient. 4The clinical features of aseptic meningitis in our patient are similar to those described with the use of rofecoxib and other NSAIDs. Symptoms appear during the first 2-3 weeks of treatment and mononuclear cells usually predominate in the cerebrospinal fluid. All meningeal and systemic signs resolve in a few days following withdrawal of the offending NSAID.The mechanism of NSAID -induced aseptic meningitis is unclear. Our patient did not have eosinophilia, urticaria, pruritus, or other clinical features to suggest a hypersensitivity reaction involving the meninges. Also, the lack of a history of NSAID allergies in our patie...
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