With a rising incidence of COVID-19–associated morbidity and mortality worldwide, it is critical to elucidate the innate and adaptive immune responses that drive disease severity. We performed longitudinal immune profiling of peripheral blood mononuclear cells from 45 patients and healthy donors. We observed a dynamic immune landscape of innate and adaptive immune cells in disease progression and absolute changes of lymphocyte and myeloid cells in severe versus mild cases or healthy controls. Intubation and death were coupled with selected natural killer cell KIR receptor usage and IgM+ B cells and associated with profound CD4 and CD8 T-cell exhaustion. Pseudo-temporal reconstruction of the hierarchy of disease progression revealed dynamic time changes in the global population recapitulating individual patients and the development of an eight-marker classifier of disease severity. Estimating the effect of clinical progression on the immune response and early assessment of disease progression risks may allow implementation of tailored therapies.

No abstract

Al Jazeera’s August 2015 editorial decision to substitute ‘refugee’ for ‘economic migrant’ in its coverage of ‘the Mediterranean Migration Crisis’ provides an opportunity to re-frame the relationship between the politics of race, immigration and media representations of refugees. Situating the broadcaster’s publicly announced rationale for the decision within a critique of the migrant–refugee dichotomy enforced by European public policy, this article, first, demonstrates that the policy couplet mobilizes oppositional yet interdependent identities. The discursive distancing of ‘migrant’ from ‘refugee’ in news content does not dislodge their mutually reinforcing power to define the parameters of ‘inclusion’. Second, the article examines how the policy onus placed on refugees to justify their claim as ‘victims’ reproduces racialized codes of belonging that perpetuate the denial of autonomy. Persons seeking refuge in Europe must sustain an identity of ‘non-threatening victim’ if they are to gain recognition in a securitized culture of (mis)trust. Al Jazeera’s intervention strengthens the media representation of refugees as human beings without choice; yet, the broadcaster’s decision to ‘give voice’ by ‘challenging racism’ does not break the European political consensus on immigration and asylum that positions ‘non-Western’ peoples as victim/pariah, to be ‘saved’ and ‘suspected’. The media–policy–migration nexus ensures that refugee exclusion is always possible.

This study explores the dynamics of racism, specifically its generation and reproduction as an ideology, and its role in affecting the reception and occupational location of migrant medical labour in Britain. It is argued that the treatment of 'overseas doctors' in Britain draws on a complex interplay between racism and nationalism underpinned by the historical construction of 'welfarism' as a moral legitimator of 'Britishness'. Through an exploration of internal and external immigration controls introduced with the aim of regulating migrant labour, we demonstrate how British social policy and elite discourses of 'race' combine to construct moral prescriptions of threat such that migrants and British-born 'non-whites' entering the British medical profession are forced to negotiate 'saviour/pariah' ascriptions indicative of discriminatory but contradictory processes specific to the operation of the British National Health Service as a normative institution.

With a rising incidence of COVID-19-associated morbidity and mortality worldwide, it is critical to elucidate the innate and adaptive immune responses that drive disease severity. We performed longitudinal immune profiling of peripheral blood mononuclear cells from 45 patients and healthy donors. We observed a dynamic immune landscape of innate and adaptive immune cells in disease progression and absolute changes of lymphocyte and myeloid cells in severe versus mild cases or healthy controls. Intubation and death were coupled with selected natural killer cell KIR receptor usage and IgM+ B cells and associated with profound CD4 and CD8 T cell exhaustion. Pseudo-temporal reconstruction of the hierarchy of disease progression revealed dynamic time changes in the global population recapitulating individual patients and the development of an eight-marker classifier of disease severity. Estimating the effect of clinical progression on the immune response and early assessment of disease progression risks may allow implementation of tailored therapies.