Please cite this article as: Moorthy A, Hogg CH, Dowling AH, Grufferty BF, Benetti AR, Fleming GJP, Cuspal deflection and microleakage in premolar teeth restored with bulk-fill flowable resin-based composite base materials., Journal of Dentistry (2010Dentistry ( ), doi:10.1016Dentistry ( /j.jdent.2012 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Page 1 of 26A c c e p t e d M a n u s c r i p t Cuspal deflection and microleakage in premolar teeth restored with bulk-fill flowable resinbased composite base materials.

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Background Glucose monitoring systems, for example, Freestyle Libre (Abott) and Dexcom (Nintamed), are increasingly being used instead of conventional blood sugar measurement. However, many patients have experienced adverse skin reactions such as severe allergic contact dermatitis (ACD). Finally, in August 2017, the culprit allergen in Freestyle Libre, isobornyl acrylate (IBOA), was identified. Objectives After patients have developed ACD, it is recommended that they no longer use their glucose monitoring systems. Thus, it is important to find an alternative IBOA‐free device. Patients and Methods Five patients presented with ACD caused by Freestyle Libre. Each was patch tested with allergens from the baseline series and from a plastics and glues series, and additionally with IBOA 0.1% pet. Gas chromatography‐mass spectrometry (GC/MS) of the Freestyle Libre sensor and the Dexcom sensor was performed. The Dexcom sensor remained on the skin of all patients for at least 2 days. Results All patients were sensitized to IBOA. GC/MS showed the presence of IBOA in the Freestyle Libre sensor, whereas the Dexcom sensor was IBOA‐free. None of the patients had skin reactions to the Dexcom sensor. Conclusions Patients with Freestyle Libre and IBOA allergy may use the Dexcom sensor as an alternative for glucose monitoring.

Ti released from dental implants can be detected in human mandibular bone and bone marrow tissues, and the distribution of Ti in human bone was related to the distance to the implant.

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New BioRoot RCS was not toxic whilst Hybrid Root SEAL demonstrated more toxicity and DNA double-strand breaks when compared with other resin- and silicate-based root canal sealers.

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