The effect of injections of hormones in utero on fetal rat kidney and liver
extramitochondrial phosphoenolpyruvate carboxykinase activity has been studied.
Glucagon and thyroxine induced the liver enzyme but none of the hormones tested
affected the renal enzyme. In the postnatal rat, the hepatic phosphoenolpyruvate carboxykinase
activity is increased after triamcinolone or thyroxine injection but only triamcinolone
injection increases the activity of the kidney enzyme. It is suggested that the rise in
renal phosphoenolpyruvate carboxykinase activity at about 10 days of age is due to the
increase in blood corticosterone content occurring at the same age.
are apparently correlated with changes in dihydroxyacetone phosphate concentration. In non-diabetic rats they are both decreased in starvation and increased 48 h after re-feeding with glucose, glycerol or sucrose. Further, in diabetes the activity of liver-type pyruvate kinase and dihydroxyacetone phosphate concentration are decreased, and in this state both are raised by treatment with insulin and by re-feeding with sucrose or glycerol but not with glucose. However, no causal relationship has been established.
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