ObjectivesSeveral genetic studies have implicated the CACNA1C SNP rs1006737 in bipolar disorder (BD) and schizophrenia (SZ) pathology. This polymorphism was recently found associated with increased amygdala activity in healthy controls and patients with BD. We performed a functional Magnetic Resonance Imaging (fMRI) study in a sample of BD and SZ cases and healthy controls to test for altered amygdala activity in carriers of the rs1006737 risk allele (AA/AG), and to investigate if there were differences across the diagnostic groups.MethodsRs1006737 was genotyped in 250 individuals (N = 66 BD, 61 SZ and 123 healthy controls), all of Northern European origin, who underwent an fMRI negative faces matching task. Statistical tests were performed with a model correcting for sex, age, diagnostic category and medication status in the total sample, and then in each diagnostic group.ResultsIn the total sample, carriers of the risk allele had increased activation in the left amygdala. Group-wise analyses showed that this effect was significant in the BD group, but not in the other diagnostic groups. However, there was no significant interaction effect for the risk allele between BD and the other groups.ConclusionsThese results indicate that CACNA1C SNP rs1006737 affects amygdala activity during emotional processing across all diagnostic groups. The current findings add to the growing body of knowledge of the pleiotropic effect of this polymorphism, and further support that ion channel dysregulation is involved in the underlying mechanisms of BD and SZ.
Has the increased public and professional awareness of the challenges of interviewing children in forensic contexts led to changes and improvements in police interviewing practices? A representative sample (n0/91) of police interviews conducted during the period of 1985 Á2002 from a large Norwegian police district was analysed. The results indicated that interviewer strategies have improved; there was a decrease in the use of suggestive, yes/no and option-posing questions and this decrease was accompanied by a comparable increase in the use of cued recall questions.The frequency of open-ended invitations was low and did not change much over time. Factors that might have led to the observed changes are briefly discussed.
The more recent focus on the link between HRM practice and organisational systems has been on the potential benefits of mutuality in employment relationships. The key to this notion of mutuality is the connection between worker well-being and performance. Although a common area of study for psychology, this relationship has received limited attention from HRM scholars. However, these initial endeavours have raised some concerns about measurement. First, there appears little consensus about which particular facet of well-being is most crucial to determining performance and, second, concern has been expressed over the validity of the different approaches taken to assessing performance. Our study addresses these issues by exploring the relationships between three different measures of well-being and two different measures of performance amongst a student cohort. Results show that life satisfaction shares a significant, positive relationship with objective performance ratings, while attentiveness, a facet of positive affect, shares a significant positive relationship with subjective performance. We explore the reasons why these different facets of well-being might be related to our different performance assessments and then, in giving consideration to these findings, discuss their implications for the measurement of well-being and of performance in workplace studies.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.