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In modern cancer therapy the clinical application of platinum-based drugs is more and more limited by the occurrence of intrinsic or acquired resistances. In this context the potential use of dinuclear platinum complexes in chemotherapy is increasingly relevant. The novel complexes Pd(Bzdpa)Cl 2 , Pd 2 (C 4 H 8 (dpa) 2 )Cl 4 , and Pt 2 (C 4 H 8 (dpa) 2 )Cl 4 allow a direct comparison of mono-and dinuclear palladium and platinum complexes respectively deriving from a 2,2Ј-dipyridylamine (Hdpa) ligand system. They were characterized by single crystal X-ray analysis as well as infrared spectroscopy and elemental analysis. The cisplatin analogous mononuclear palladium complex Pd(Bzdpa)Cl 2 (1) (Bzdpa: (2,2Јdipyridylbenzyl)amine) belongs to a range of 2,2Ј-dipyridylaminebased compounds which were extensively studied in our laborato-

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The reactions of [Pt(dpma)(H 2 O) 2 ] 2+ (dpma = 2,2'dipyridylmethylamine) and [Pt(dpk)(H 2 O) 2 ] 2+ (dpk = 2,2'-dipyridylketone) with the model nucleobases 1-methylthymine (1-MeT) and 1-methyluracil (1-MeU) were studied. Reaction products were characterized by 195 Pt NMR spectroscopy and by X-ray structure analysis. The symmetric dpma and dpk diaqua complexes form dinuclear complexes with 1-methylthymine, acting as secondary bridging ligand via its N3 and O4 donor atoms. [Pt 2 (dpma) 2 (1-MeT) 2 ](ClO 4 ) 2H 2 O (5) and [Pt 2 (dpk)(dpk´H 2 O)(1-MeT) 2 ](PF 6 ) 2´4 H 2 O (6) both show a head-to-head arrangement. Biological tests show a significant in vitro antitumor activity of [Pt(dpk)Cl 2 ] against the human glioma cell line U 87. Platin(II)-Komplexe mit Dipyridyl-Ligandsystemen und ihre Produkte mit den Modell-Nukleobasen 1-Methylthymin und 1-Methyluracil Inhaltsu È bersicht. Die Reaktionen von [Pt(dpma)(H 2 O) 2 ] 2+ (dpma = 2,2'-Dipyridylmethylamin) und [Pt(dpk)(H 2 O) 2 ] 2+ (dpk = 2,2'-Dipyridylketon) mit den Modell-Nukleobasen 1-Methylthymin und 1-Methyluracil wurden untersucht und die Reaktionsprodukte 195 Pt-NMR-spektroskopisch und ro È ntgenstrukturanalytisch charakterisiert. Die symmetrischen Diaquakomplexe der Ligandsysteme dpma und dpk bilden dinukleare Komplexe mit 1-Methylthymin. Die Modellnukleobase fungiert als zweiter verbru È ckender Ligand u È ber die N3-und O4-Donoratome. [Pt 2 (dpma) 2 (1-MeT) 2 ]-(ClO 4 ) 2´H2 O (5) und [Pt 2 (dpk)(dpk´H 2 O)(1-MeT) 2 ]-(PF 6 ) 2´4 H 2 O (6) zeigen beide eine Kopf±Kopf-Anordnung bezu È glich der Modell-Nukleobase. In biologischen Tests weist der Komplex [Pt(dpk)Cl 2 ] eine signifikante in vitro Antitumoraktivita È t an der Zellinie U 87 auf.

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