Peripheral T-cell lymphoma (PTCL) encompasses a group of rare and aggressive lymphomas. PTCL, unspecified (PTCLU) is the most common subtype of PTCL, and carries a poor prognosis. The International Prognostic Index (IPI) and the Prognostic Index for PTCLU (PIT) scoring systems are powerful risk-stratification tools in patients with PTCL. The aim of this study was to evaluate whether the neutrophil-to-lymphocyte ratio (NLR) is a prognostic factor in PTCLU. We retrospectively studied 83 patients with diagnosis of PTCLU. In the univariate analysis, NLR ≥ 4 was associated with worse overall survival (HR 3.96, 95% CI 1.92-8.17; p < 0.001). In the multivariate analysis, NLR ≥ 4 was independently associated with worse overall survival after adjustment for the PIT score (HR 4.30, 95% CI 1.90-9.69; p < 0.001), and for the IPI score (HR 2.60, 95% CI 1. 12-6.04; p = 0.03). Our study suggests the NLR could be helpful in refining the survival prognostication in patients with PTCLU.

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Although the benefits of morphing wings have been proven in many studies in the last few decades, the wing skin design remains one of the challenges to advancing and implementing the morphing technology. This is due to the conflicting design requirements of high out-of-plane stiffness to withstand aerodynamic loads and low in-plane stiffness to allow morphing with the available actuation forces. Advancements in the design of hybrid and flexible composites might allow for design solutions that feature this balance in stiffness required for this application. These composites offer new design parameters, such as the number of plies, the fiber-orientation angle of each ply in the skin laminate, and the spatial distribution of the plies on the skin surface. This paper presents a parametric study of a composite skin for a twist-morphing wing. The skin is made of periodic laminated composite sections, called “Twistkins”, integrated in an elastomeric outer skin. The twisting deformation is localized in the elastomeric sections between the Twistkins. The design parameters considered are the number of plies in the composite Twistkins, the fiber-orientation angle of the plies, the torsional rigidity of the elastomer, the width ratio, and the number of elastomeric sections. The computational analysis results showed that the torsional compliance can be increased by increasing the width ratio, decreasing the number of elastomeric sections, number of composite plies and the elastomer’s torsional rigidity. However, this would also lead to a decrease in the out-of-plane stiffness. The nonlinearity and rates at which these parameters affect the skin’s behavior are highlighted, including the effect of the fiber-orientation angle of the laminate plies. Hence, the study guides the design process of this twist-morphing skin.

We have been unable to find a report of a larger gallstone in the English or Spanish language medical literature.