Mannitol, an osmotic agent and a free radical scavenger with neuroprotective properties, have been reported in many studies to decrease cerebral oedema , infarct size and neurological deficit in patients with stroke. The present study was carried out in the Department of Pharmacology and Therapeutics in collaboration with the Departments of Medicine and Neurology of Sylhet M.A.G Osmani Medical College and Hospital to evaluate the effect of mannitol on serum electrolytes in stroke patients. A total number of Forty five (45) acute stroke patients were randomly allocated in two groups- 23 patients received mannitol and 22 patients did not receive mannitol. On Day 1 after measuring serum electrolyte levels of both groups, mannitol receiving group was given infusion mannitol 1 gm/kg IV bolus followed by 0.5 gm/kg IV 6 hourly till 3rd day and then again on Day 3 serum electrolyte levels of both groups were measured. Predisposing risk factors, egsmoking, hypertension, dyslipidaemia were also analyzed. RBS (Random Blood Sugar) and serum creatinine were estimated before treatment initiation with aim to assess hyperglycaemia and renal impairment respectively. Statistical analysis was done by SPSS program using unpaired ‘t’ test between two groups and between Day 1 and Day 3 by paired ‘t’ test. The result showed that serum sodium and potassium at Day 1 and Day 3 were almost similar between mannitol receiving group and mannitol non-receiving group ( P>0.05 for each component). After infusion of mannitol till third day, no electrolyte imbalance was noted. The study depicts that mannitol can be safely given to stroke patients as there were no change in electrolyte balance till third day. Bangladesh Journal of Neuroscience 2016; Vol. 32 (1): 21-27
Background:Acute coronary syndrome is a cardiac emergency. It is increasing dramatically and becoming a major burden in our health care system. Relation between serum lipid profile and acute coronary syndrome is well established. Our study tried to reveal association of high density lipoprotein cholesterol (HDL-C) with in-hospital outcome of patients with acute coronary syndrome. Methods: The study was a cross sectional comparative study. Clinical & biochemical evaluation was done in hospital settings. A total number of 271 patients were included in the study and divided into two groups. Patients with low HDL-C level were in group I and patients with normal HDL-C were in group II. Results: Group I populations had more complications & more in-hospital stay than group II (74.3% vs 28.9%, P<0.001 and 6.65±2.04 days vs 5.09±1.44 days, p<0.001 respectively). Conclusion: The study revealed significant association of HDL-C with outcome of acute coronary syndrome patients. Complications of acute coronary syndrome were more in patients with low HDL-C level.
Sickle cell anemia is the most common genetic disorder that affects hemoglobin. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent shape. Sickle cell disease is an increasing global health problem. Estimates suggest that every year approximately 300,000 infants are born with sickle cell anemia, which is defined as an autosomal recessive disorder. The objective of this study is to show that the newborn screening of sickle cell anemia is possible through the procedure by utilizing the cord blood. Materials and Methods:A total number of 30 samples were collected from individual mother and cord blood. DNA was extracted from 13 mothers and 13 fetal cord blood samples and used these DNA to detect sickle cell anemia using wild type and mutant type primer.Results: β hemoglobin gene was amplified by wild type and mutant type primer using PCR and revealed 517bp and 267bp length DNA fragments, respectively. In this study, it was observed that only one homozygous (Hb S/S) mother and newborn found. Most of the mothers and newborns were carrier of sickle cell anemia which means they were heterozygous (Hb A/S). Two pairs were found where mother was carrier, but newborns were healthy (Hb A/A). Conclusions:With this study, it can come to the point that the newborn screening of sickle cell anemia is possible through the procedure by utilizing the cord blood that is wasted every time during delivery. By maternal screening in this way, the probability of disease transmission can also be checked earlier. For Bangladesh, this approach can be an effective tool for screening sickle cell anemia.
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