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Quick and parallel genotyping of human papilloma virus (HPV) type 16/18 is carried out by a specially designed giant magnetoimpedance (GMI) based microchannel system. Micropatterned soft magnetic ribbon exhibiting large GMI ratio serves as the biosensor element. HPV genotyping can be determined by the changes in GMI ratio in corresponding detection region after hybridization. The result shows that this system has great potential in future clinical diagnostics and can be easily extended to other biomedical applications based on molecular recognition.

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As a classic Earth magnetic field sensor, fluxgate magnetic sensors have great potential applications in many fields. This paper presents a new 3D micro-solenoid fluxgate magnetic sensor based on the MEMS technique. The excitation coils were placed vertically to the detection coils on the chip plane, around a rectangular shaped magnetic core. Polyimide was used to insulate coils and magnetic core. Width of copper conductor lines is 50 lm, and line space is 50 lm. The design of such fluxgate magnetic sensor followed second harmonic signal selecting method. Phase-lock amplifier was used to get second harmonic signal output by detection coils. The linear range of 0-80 lT with sensitivity of 6.7 V/T was achieved from the fabricated sensor with excitation current of 430 mA and the operational frequency of 40 KHz. As the excitation current was 470 mA, linear range of 0-50 lT with sensitivity of 21.7 V/T was achieved.

This paper presents an approach to detect the presence of Dynabeads with a system based on a micro fluxgate sensor fabricated by micro-electro-mechanical systems technology. Due to the excellent performance of the micro fluxgate sensor, the detection system exhibited many advantages, such as lower minimum detectable limit, small weight, and low power consumption. Experimental results show that, applied an external magnetic field in a range of 430 μT to 600 μT, Dynabeads with a concentration as low as 0.1 μg/ml can be detected by this system. Moreover, the detection system could give an approximate quantitation to the magnetic beads.