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Background: Vascular permeability factor/Vascular endothelial growth factor (VPF/VEGF), a multifunctional cytokine, is a potent inducer of vascular permeability, an important early step in angiogenesis. It is known that the neurotransmitter dopamine can inhibit VPF/VEGF mediated angiogenesis, in particular microvascular permeability, but the effectors of this action remain unclear.

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Results of laboratory model tests to determine the ultimate bearing capacity of shallow strip foundation supported by sand and subjected to eccentrically inclined load are presented. The tests were conducted in dense and medium dense sands. The embedment ratio (ratio of the depth of embedment D f to the width of the foundation B) was varied from zero to one. The load eccentricity e was varied from zero to 0.15B as well as the load inclination from zero to 20 degrees. Based on the results of the present study, an empirical nondimensional reduction factor has been developed. This reduction factor is the ratio of the ultimate bearing capacity of the foundation subjected to an eccentrically inclined load to the ultimate bearing capacity of the foundation subjected to a centric vertical load.