Context:Analysis of diagnostic ability of macular ganglionic cell complex and retinal nerve fiber layer (RNFL) in glaucoma.Aim:To correlate functional and structural parameters and comparing predictive value of each of the structural parameters using Fourier-domain (FD) optical coherence tomography (OCT) among primary open angle glaucoma (POAG) and ocular hypertension (OHT) versus normal population.Setting and Design:Single centric, cross-sectional study done in 234 eyes.Materials and Methods:Patients were enrolled in three groups: POAG, ocular hypertensive and normal (40 patients in each group). After comprehensive ophthalmological examination, patients underwent standard automated perimetry and FD-OCT scan in optic nerve head and ganglion cell mode. The relationship was assessed by correlating ganglion cell complex (GCC) parameters with mean deviation. Results were compared with RNFL parameters.Statistical Analysis:Data were analyzed with SPSS, analysis of variance, t-test, Pearson's coefficient, and receiver operating curve.Results:All parameters showed strong correlation with visual field (P < 0.001). Inferior GCC had highest area under curve (AUC) for detecting glaucoma (0.827) in POAG from normal population. However, the difference was not statistically significant (P > 0.5) when compared with other parameters. None of the parameters showed significant diagnostic capability to detect OHT from normal population. In diagnosing early glaucoma from OHT and normal population, only inferior GCC had statistically significant AUC value (0.715).Conclusion:In this study, GCC and RNFL parameters showed equal predictive capability in perimetric versus normal group. In early stage, inferior GCC was the best parameter. In OHT population, single day cross-sectional imaging was not valuable.

Objectives: To evaluate the correlation between Glycosy lated Haemoglobin (HbA1c) level and central foveal thickness measured by Optical coherence tomography (OCT) in patients with type 2 diabetes mellitus. Materials and methods: This was a retrospective single center study of 6 month duration including patients of pre-proliferative stage of type 2 diabetes mellitus. Clinically significant macular oedema (CSME) was diagnosed by using OCT. OCT examination by 'RT optovue, Fremont, CA' and HbA1c measured by specific high-pressure liquid chromatography methods. If patient have both eye macular oedema, eye with thicker macular oedema was used for statistical analysis. Exclusion of patients who received intraocular surgery, cataract surgery, pars plana vitrectomy, Severe vitreous haemorrhage, etc. Results: One hundred four eyes of 104 patients were included in this cross-sectional study. The mean Age ±SD was 62.3±8.1 years (range, 40-77 years). Mean value of HbA1c was 7.8%±1.4% (range, 5.1%-12.1%). Mean DM duration was 11.2±5.5 years (range, 1-30 years). Mean central retinal thickness was 257.1±79.3 μm (range, 151-526 μm). Univariate analysis was significant with HbA1C level (7 or over) (P=0.005). Not statistically significant with Sex (P=0.78), Right or left eye (P=0.59). Conclusion: Patients with HbA1c of 7% or above had an increase in macular thickness as measured by OCT in shorter DM duration (< 10 years). Its association with macular oedema is statistically significant. Good sugar control decreased the risk of diabetic macular oedema.